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Immunology and Infection

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JoVE Journal Immunology and Infection
In vivo augmentation af Gut-homing regulerende T-celle induktion
 
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In vivo augmentation af Gut-homing regulerende T-celle induktion

Article DOI: 10.3791/60585-v • 08:02 min • January 22nd, 2020
January 22nd, 2020 •
1,2, 1, 1, 1,3,4, 1,3
1Division of Regenerative Medicine, Department of Medicine, Loma Linda University, 2Zhengzhou University, 3Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, Long Island University, 4Jinan Infectious Disease Hospital, Shandong University

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Her præsenterer vi en protokol for in vivo augmentation af Gut-homing regulatoriske T-celle induktion. I denne protokol er dendritiske celler konstrueret til lokalt at producere høje koncentrationer af det aktive vitamin D (1,25-dihydroxyvitamin D eller 1,25 [OH]2D) og den aktive vitamin a (RETINSYRE eller RA) de Novo.

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Immunologi og infektion Gut-homing regulerende T-celler 25-hydroxyvitamin d 1α-hydroxylase cytochrom P450 familie 27 familien B medlem 1 1 25-dihydroxyvitamin D foxp3 dendritiske celler retinaldehyd dehydrogenase 2 c-c chemokine receptor type 9
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