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Immunology and Infection

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JoVE Journal Immunology and Infection
Etablierung eines Porcine Ex Vivo Cornea Modells zur Untersuchung von medikamentösen Behandlungen gegen bakterielle Keratitis
 
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Etablierung eines Porcine Ex Vivo Cornea Modells zur Untersuchung von medikamentösen Behandlungen gegen bakterielle Keratitis

Article DOI: 10.3791/61156-v • 09:22 min • May 12th, 2020
May 12th, 2020 •
1,2, 3, 4, 1,5, 3, 1,6, 1,7, 1,2
1Sheffield Collaboratorium for Antimicrobial Resistance and Biofilms (SCARAB), University of Sheffield, 2Department of Chemical and Biological Engineering, University of Sheffield, 3Hyderabad Eye Research Foundation, L V Prasad Eye Institute, 4Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, 5Department of Molecular Biology and Biotechnology, University of Sheffield, 6Department of Materials Science and Engineering, University of Sheffield, 7Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield

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Dieser Artikel beschreibt ein Schritt-für-Schritt-Protokoll zur Einrichtung eines Ex-vivo-Schweinemodells der bakteriellen Keratitis. Pseudomonas aeruginosa wird als prototypischer Organismus verwendet. Dieses innovative Modell imitiert in vivo-Infektionen, da die bakterielle Proliferation von der Fähigkeit des Bakteriums abhängt, Hornhautgewebe zu schädigen.

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Immunologie und Infektion Ausgabe 159 Pseudomonas aeruginosa Keratitis Hornhaut ex vivo Auge Schwein
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