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JoVE Journal Genetics
Demonstratie van de sequentie-uitlijning om te voorspellen tussen soorten gevoeligheidsinstrument voor snelle beoordeling van eiwitbehoud
 
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Demonstratie van de sequentie-uitlijning om te voorspellen tussen soorten gevoeligheidsinstrument voor snelle beoordeling van eiwitbehoud

Article DOI: 10.3791/63970-v • 16:02 min • February 10th, 2023
February 10th, 2023 •
1, 2, 2, 3, 4, 5, 5, 5, 6
1Office of Research and Development, Center for Computational Toxicology and Exposure, Scientific Computing and Data Curation Division, U.S. Environmental Protection Agency, 2Oak Ridge Institute for Science and Education, 3Swenson College of Science and Engineering, Department of Biology, University of Minnesota Duluth, 4University of Wisconsin-Madison Aquatic Sciences Center, 5General Dynamics Information Technology, Research Triangle Park, 6Office of Research and Development, Center for Computational Toxicology and Exposure, Great Lakes Toxicology and Ecology Division, U.S. Environmental Protection Agency

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Hier presenteren we een protocol om de nieuwste versie van de Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) -tool van het Amerikaanse Environmental Protection Agency te gebruiken. Dit protocol demonstreert de toepassing van de online tool om snel eiwitbehoud te analyseren en aanpasbare en gemakkelijk interpreteerbare voorspellingen van chemische gevoeligheid tussen soorten te bieden.

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Genetica Nummer 192 Cross-species extrapolatie ecotoxicologie voorspellende toxicologie nieuwe benaderingsmethodologie opioïde receptor transthyretine
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