Augustine M.K. Choi Department of Medicine, Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital Harvard Medical School Biography Publications Institution JoVE Articles Augustine M.K. Choi has not added a biography. If you are Augustine M.K. Choi and would like to personalize this page please email our Author Liaison for assistance. Publications Autophagic Proteins: New Facets of the Oxygen Paradox Autophagy. Mar, 2012 | Pubmed ID: 22302001 Allele Specific Transactivation of Matrix Metalloproteinase 7 by FOXA2 and Correlation with Plasma Levels in Idiopathic Pulmonary Fibrosis American Journal of Physiology. Lung Cellular and Molecular Physiology. Jan, 2012 | Pubmed ID: 22268124 Statins and Pulmonary Fibrosis: The Potential Role of NLRP3 Inflammasome Activation American Journal of Respiratory and Critical Care Medicine. Jan, 2012 | Pubmed ID: 22246178 Autophagy in Pulmonary Diseases Annual Review of Physiology. Mar, 2012 | Pubmed ID: 22035347 Autophagy: Cellular Defense to Excessive Inflammation Microbes and Infection / Institut Pasteur. Feb, 2012 | Pubmed ID: 21924374 Genetically Manipulated Mouse Models of Lung Disease: Potential and Pitfalls American Journal of Physiology. Lung Cellular and Molecular Physiology. Dec, 2011 | Pubmed ID: 22198907 Identification of a Chronic Obstructive Pulmonary Disease Genetic Determinant That Regulates HHIP Human Molecular Genetics. Dec, 2011 | Pubmed ID: 22140090 Hyperoxia Induced LC3B Interacts with the Fas Apoptotic Pathway in Epithelial Cell Death American Journal of Respiratory Cell and Molecular Biology. Nov, 2011 | Pubmed ID: 22095627 Nucleotide-binding Oligomerization Domain Protein 2 Deficiency Enhances Neointimal Formation in Response to Vascular Injury Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2011 | Pubmed ID: 21903945 Autophagy: a Core Cellular Process with Emerging Links to Pulmonary Disease American Journal of Respiratory and Critical Care Medicine. Dec, 2011 | Pubmed ID: 21836133 Beclin 1 Deficiency is Associated with Increased Hypoxia-induced Angiogenesis Autophagy. Aug, 2011 | Pubmed ID: 21685724 Dampening Insulin Signaling by an NLRP3 'meta-flammasome' Nature Immunology. May, 2011 | Pubmed ID: 21502990 Characterization of Macroautophagic Flux in Vivo Using a Leupeptin-based Assay Autophagy. Jun, 2011 | Pubmed ID: 21460622 Carbon Monoxide Activates Autophagy Via Mitochondrial Reactive Oxygen Species Formation American Journal of Respiratory Cell and Molecular Biology. Oct, 2011 | Pubmed ID: 21441382 Caveolin-1 Mediates Fas-BID Signaling in Hyperoxia-induced Apoptosis Free Radical Biology & Medicine. May, 2011 | Pubmed ID: 21382479 Deadly Triplex: Smoke, Autophagy and Apoptosis Autophagy. Apr, 2011 | Pubmed ID: 21200154 Autophagy Proteins Regulate Innate Immune Responses by Inhibiting the Release of Mitochondrial DNA Mediated by the NALP3 Inflammasome Nature Immunology. Mar, 2011 | Pubmed ID: 21151103 Caveolin-1: a Critical Regulator of Lung Injury American Journal of Physiology. Lung Cellular and Molecular Physiology. Feb, 2011 | Pubmed ID: 21097526 Autophagic Protein LC3B Confers Resistance Against Hypoxia-induced Pulmonary Hypertension American Journal of Respiratory and Critical Care Medicine. Mar, 2011 | Pubmed ID: 20889906 Bronchoprovocation Testing in Asthma: Effect on Exhaled Monoxides Journal of Breath Research. Dec, 2010 | Pubmed ID: 21383491 Autophagy Protein Microtubule-associated Protein 1 Light Chain-3B (LC3B) Activates Extrinsic Apoptosis During Cigarette Smoke-induced Emphysema Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010 | Pubmed ID: 20956295 Evaluation of Inhaled Carbon Monoxide As an Anti-inflammatory Therapy in a Nonhuman Primate Model of Lung Inflammation American Journal of Physiology. Lung Cellular and Molecular Physiology. Dec, 2010 | Pubmed ID: 20729385 Heme Oxygenase-1/carbon Monoxide: Novel Therapeutic Strategies in Critical Care Medicine Current Drug Targets. Dec, 2010 | Pubmed ID: 20704552 Inhaled Hydrogen Sulfide Protects Against Ventilator-induced Lung Injury Anesthesiology. Jul, 2010 | Pubmed ID: 20574227 Autophagy in Vascular Disease Proceedings of the American Thoracic Society. Feb, 2010 | Pubmed ID: 20160147 Autophagy in the Lung Proceedings of the American Thoracic Society. Feb, 2010 | Pubmed ID: 20160144 Nitrite Potently Inhibits Hypoxic and Inflammatory Pulmonary Arterial Hypertension and Smooth Muscle Proliferation Via Xanthine Oxidoreductase-dependent Nitric Oxide Generation Circulation. Jan, 2010 | Pubmed ID: 20026772 Integration of Genomic and Genetic Approaches Implicates IREB2 As a COPD Susceptibility Gene American Journal of Human Genetics. Oct, 2009 | Pubmed ID: 19800047 NHLBI Workshop: Respiratory Medicine-related Research Training for Adult and Pediatric Fellows Lung. Nov-Dec, 2009 | Pubmed ID: 19763688 The Influence of Radiographic Phenotype and Smoking Status on Peripheral Blood Biomarker Patterns in Chronic Obstructive Pulmonary Disease PloS One. 2009 | Pubmed ID: 19718453 Fatty Acids Modulate Toll-like Receptor 4 Activation Through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19648648 The Fibrotic Phenotype Induced by IGFBP-5 is Regulated by MAPK Activation and Egr-1-dependent and -independent Mechanisms The American Journal of Pathology. Aug, 2009 | Pubmed ID: 19628764 Heme Oxygenase-1/carbon Monoxide: from Metabolism to Molecular Therapy American Journal of Respiratory Cell and Molecular Biology. Sep, 2009 | Pubmed ID: 19617398 Lipid-soluble Components in Cigarette Smoke Induce Mitochondrial Production of Reactive Oxygen Species in Lung Epithelial Cells American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2009 | Pubmed ID: 19411310 Heme Oxygenase-1, a Critical Arbitrator of Cell Death Pathways in Lung Injury and Disease Free Radical Biology & Medicine. Jul, 2009 | Pubmed ID: 19362144 Carbon Monoxide Prevents Ventilator-induced Lung Injury Via Caveolin-1 Critical Care Medicine. May, 2009 | Pubmed ID: 19325477 The Heme Oxygenase-1/carbon Monoxide Pathway Suppresses TLR4 Signaling by Regulating the Interaction of TLR4 with Caveolin-1 Journal of Immunology (Baltimore, Md. : 1950). Mar, 2009 | Pubmed ID: 19265160 Analyzing Autophagy in Clinical Tissues of Lung and Vascular Diseases Methods in Enzymology. 2009 | Pubmed ID: 19216908 Discovery of the Gene Signature for Acute Lung Injury in Patients with Sepsis Physiological Genomics. Apr, 2009 | Pubmed ID: 19174476 Carbon Monoxide Modulates Alpha-smooth Muscle Actin and Small Proline Rich-1a Expression in Fibrosis American Journal of Respiratory Cell and Molecular Biology. Jul, 2009 | Pubmed ID: 19097987 Autophagy in Chronic Obstructive Pulmonary Disease: Homeostatic or Pathogenic Mechanism? Autophagy. Feb, 2009 | Pubmed ID: 19066468 Caveolin-1 Regulates the Secretion and Cytoprotection of Cyr61 in Hyperoxic Cell Death FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2009 | Pubmed ID: 18801924 Sphingosine 1-phosphate Rescues Canine LPS-induced Acute Lung Injury and Alters Systemic Inflammatory Cytokine Production in Vivo Translational Research : the Journal of Laboratory and Clinical Medicine. Nov, 2008 | Pubmed ID: 19010292 Identifying Targets for COPD Treatment Through Gene Expression Analyses International Journal of Chronic Obstructive Pulmonary Disease. 2008 | Pubmed ID: 18990963 Egr-1 Regulates Autophagy in Cigarette Smoke-induced Chronic Obstructive Pulmonary Disease PloS One. 2008 | Pubmed ID: 18830406 Network Analysis of Temporal Effects of Intermittent and Sustained Hypoxia on Rat Lungs Physiological Genomics. Dec, 2008 | Pubmed ID: 18826996 CX3CL1 Up-regulation is Associated with Recruitment of CX3CR1+ Mononuclear Phagocytes and T Lymphocytes in the Lungs During Cigarette Smoke-induced Emphysema The American Journal of Pathology. Oct, 2008 | Pubmed ID: 18772344 Autophagic Proteins Regulate Cigarette Smoke-induced Apoptosis: Protective Role of Heme Oxygenase-1 Autophagy. Oct, 2008 | Pubmed ID: 18769149 Inducing Hypoxemia in Healthy Humans: a Method for Intermittently Lowering Arterial Blood Oxygenation During Physiological Studies Wilderness & Environmental Medicine. 2008 | Pubmed ID: 18715123 Ex Vivo Carbon Monoxide Prevents Cytochrome P450 Degradation and Ischemia/reperfusion Injury of Kidney Grafts Kidney International. Oct, 2008 | Pubmed ID: 18633343 Carbon Monoxide Ameliorates Renal Cold Ischemia-reperfusion Injury with an Upregulation of Vascular Endothelial Growth Factor by Activation of Hypoxia-inducible Factor Transplantation. Jun, 2008 | Pubmed ID: 18580478 Non-invasive Measurements of Exhaled NO and CO Associated with Methacholine Responses in Mice Respiratory Research. 2008 | Pubmed ID: 18505586 Carbon Monoxide Protects Against Ventilator-induced Lung Injury Via PPAR-gamma and Inhibition of Egr-1 American Journal of Respiratory and Critical Care Medicine. Jun, 2008 | Pubmed ID: 18356564 Protein Kinase C Alpha and Zeta Differentially Regulate Death-inducing Signaling Complex Formation in Cigarette Smoke Extract-induced Apoptosis Journal of Immunology (Baltimore, Md. : 1950). Apr, 2008 | Pubmed ID: 18354190 Deletion of Caveolin-1 Protects Against Oxidative Lung Injury Via Up-regulation of Heme Oxygenase-1 American Journal of Respiratory Cell and Molecular Biology. Aug, 2008 | Pubmed ID: 18323531 Caveolin-1 Stops Profibrogenic Signaling? American Journal of Physiology. Lung Cellular and Molecular Physiology. May, 2008 | Pubmed ID: 18296500 Caveolin-1: a Critical Regulator of Pulmonary Vascular Architecture and Nitric Oxide Bioavailability in Pulmonary Hypertension American Journal of Physiology. Lung Cellular and Molecular Physiology. May, 2008 | Pubmed ID: 18296499 Mitogen-activated Protein Kinases Regulate Susceptibility to Ventilator-induced Lung Injury PloS One. 2008 | Pubmed ID: 18270588 Inhaled CO in the Treatment of Acute Lung Injury American Journal of Physiology. Lung Cellular and Molecular Physiology. Apr, 2008 | Pubmed ID: 18263669 Gene Expression Profiling in Chronic Obstructive Pulmonary Disease American Journal of Respiratory and Critical Care Medicine. Feb, 2008 | Pubmed ID: 18250352 Nitric Oxide-deficiency Regulates Hepatic Heme Oxygenase-1 Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. Feb, 2008 | Pubmed ID: 17999922 Functional Significance of Apoptosis in Chronic Obstructive Pulmonary Disease COPD. Dec, 2007 | Pubmed ID: 18027162 A New Road to Induce Heme Oxygenase-1 Expression by Carbon Monoxide Circulation Research. Oct, 2007 | Pubmed ID: 17967796 Inverse Association of Plasma IL-13 and Inflammatory Chemokines with Lung Function Impairment in Stable COPD: a Cross-sectional Cohort Study Respiratory Research. 2007 | Pubmed ID: 17868461 Protective Functions of Heme Oxygenase-1 and Carbon Monoxide in the Respiratory System Antioxidants & Redox Signaling. Dec, 2007 | Pubmed ID: 17845132 Carbon Monoxide in Sepsis Antioxidants & Redox Signaling. Nov, 2007 | Pubmed ID: 17822362 Cellular and Humoral Autoreactivity in Idiopathic Pulmonary Fibrosis Journal of Immunology (Baltimore, Md. : 1950). Aug, 2007 | Pubmed ID: 17675522 MAPK Pathway Mediates EGR-1-HSP70-dependent Cigarette Smoke-induced Chemokine Production American Journal of Physiology. Lung Cellular and Molecular Physiology. May, 2007 | Pubmed ID: 17494953 FLIP Inhibits Endothelial Cell Apoptosis During Hyperoxia by Suppressing Bax Free Radical Biology & Medicine. May, 2007 | Pubmed ID: 17448907 Cytoprotective and Anti-inflammatory Actions of Carbon Monoxide in Organ Injury and Sepsis Models Novartis Foundation Symposium. 2007 | Pubmed ID: 17380794 Hemodynamic and Molecular Response to Intermittent Hypoxia (IH) Versus Continuous Hypoxia (CH) in Normal Humans Translational Research : the Journal of Laboratory and Clinical Medicine. Feb, 2007 | Pubmed ID: 17240318 Carbon Monoxide Protects Against Hyperoxia-induced Endothelial Cell Apoptosis by Inhibiting Reactive Oxygen Species Formation The Journal of Biological Chemistry. Jan, 2007 | Pubmed ID: 17135272 Mechanisms of Cell Death in Oxidative Stress Antioxidants & Redox Signaling. Jan, 2007 | Pubmed ID: 17115887 Cigarette Smoke Stimulates Matrix Metalloproteinase-2 Activity Via EGR-1 in Human Lung Fibroblasts American Journal of Respiratory Cell and Molecular Biology. Apr, 2007 | Pubmed ID: 17099140 Mitochondrial Localization and Function of Heme Oxygenase-1 in Cigarette Smoke-induced Cell Death American Journal of Respiratory Cell and Molecular Biology. Apr, 2007 | Pubmed ID: 17079780 Carbon Monoxide and Bilirubin: Potential Therapies for Pulmonary/vascular Injury and Disease American Journal of Respiratory Cell and Molecular Biology. Feb, 2007 | Pubmed ID: 16980550 Caveolin-1: a Critical Regulator of Lung Fibrosis in Idiopathic Pulmonary Fibrosis The Journal of Experimental Medicine. Dec, 2006 | Pubmed ID: 17178917 Insulin-like Growth Factor-binding Protein-5 Induces Pulmonary Fibrosis and Triggers Mononuclear Cellular Infiltration The American Journal of Pathology. Nov, 2006 | Pubmed ID: 17071587 Carbon Monoxide Differentially Inhibits TLR Signaling Pathways by Regulating ROS-induced Trafficking of TLRs to Lipid Rafts The Journal of Experimental Medicine. Oct, 2006 | Pubmed ID: 17000866 Protective Effect of Carbon Monoxide in Transplantation Journal of Cellular and Molecular Medicine. Jul-Sep, 2006 | Pubmed ID: 16989726 Heat-shock Proteins: New Keys to the Development of Cytoprotective Therapies Expert Opinion on Therapeutic Targets. Oct, 2006 | Pubmed ID: 16981832 Insulin-like Growth Factor Binding Protein 5 Induces Skin Fibrosis: A Novel Murine Model for Dermal Fibrosis Arthritis and Rheumatism. Sep, 2006 | Pubmed ID: 16947625 Comprehensive Analysis of Gene Expression on GOLD-2 Versus GOLD-0 Smokers Reveals Novel Genes Important in the Pathogenesis of COPD Proceedings of the American Thoracic Society. Aug, 2006 | Pubmed ID: 16921106 Low-dose Carbon Monoxide Inhalation Prevents Ischemia/reperfusion Injury of Transplanted Rat Lung Grafts Surgery. Aug, 2006 | Pubmed ID: 16904967 A Peptide with Anti-transglutaminase Activity Decreases Lipopolysaccharide-induced Lung Inflammation in Mice Experimental Lung Research. Jan-Feb, 2006 | Pubmed ID: 16809220 Heme Oxygenase-1/carbon Monoxide: from Basic Science to Therapeutic Applications Physiological Reviews. Apr, 2006 | Pubmed ID: 16601269 Therapeutic Applications of Carbon Monoxide in Lung Disease Current Opinion in Pharmacology. Jun, 2006 | Pubmed ID: 16580257 Gene Expression Profiling of Target Genes in Ventilator-induced Lung Injury Physiological Genomics. Jun, 2006 | Pubmed ID: 16569776 CCAAT/enhancer-binding Protein Mediates Carbon Monoxide-induced Suppression of Cyclooxygenase-2 American Journal of Respiratory Cell and Molecular Biology. Aug, 2006 | Pubmed ID: 16543610 Heart Allograft Protection with Low-dose Carbon Monoxide Inhalation: Effects on Inflammatory Mediators and Alloreactive T-cell Responses Transplantation. Jan, 2006 | Pubmed ID: 16436966 CO As a Cellular Signaling Molecule Annual Review of Pharmacology and Toxicology. 2006 | Pubmed ID: 16402911 Caveolin-1 Confers Antiinflammatory Effects in Murine Macrophages Via the MKK3/p38 MAPK Pathway American Journal of Respiratory Cell and Molecular Biology. Apr, 2006 | Pubmed ID: 16357362 Low-dose Carbon Monoxide Inhalation Prevents Development of Chronic Allograft Nephropathy American Journal of Physiology. Renal Physiology. Feb, 2006 | Pubmed ID: 16131650 Global Gene Expression Profiles Reveal Pathways Related to the Pathogenesis of Chronic Obstructive Pulmonary Disease Discovery Medicine. Feb, 2005 | Pubmed ID: 20704930 Cytoprotection of Heme Oxygenase-1/carbon Monoxide in Lung Injury Proceedings of the American Thoracic Society. 2005 | Pubmed ID: 16222043 Heat Shock Protein-70 Mediates the Cytoprotective Effect of Carbon Monoxide: Involvement of P38 Beta MAPK and Heat Shock Factor-1 Journal of Immunology (Baltimore, Md. : 1950). Aug, 2005 | Pubmed ID: 16081837 Caveolin-1 Expression by Means of P38beta Mitogen-activated Protein Kinase Mediates the Antiproliferative Effect of Carbon Monoxide Proceedings of the National Academy of Sciences of the United States of America. Aug, 2005 | Pubmed ID: 16051704 Carbon Monoxide Inhibits IL-17-induced IL-6 Production Through the MAPK Pathway in Human Pulmonary Epithelial Cells American Journal of Physiology. Lung Cellular and Molecular Physiology. Aug, 2005 | Pubmed ID: 16003000 Alterations in Nitric Oxide and Cytokine Production with Airway Inflammation in the Absence of IL-10 Journal of Immunology (Baltimore, Md. : 1950). Jul, 2005 | Pubmed ID: 16002724 Cyr61 Protects Against Hyperoxia-induced Cell Death Via Akt Pathway in Pulmonary Epithelial Cells American Journal of Respiratory Cell and Molecular Biology. Sep, 2005 | Pubmed ID: 15961723 Brief Inhalation of Low-dose Carbon Monoxide Protects Rodents and Swine from Postoperative Ileus Critical Care Medicine. Jun, 2005 | Pubmed ID: 15942350 "Therapeutic" Carbon Monoxide May Be a Reality Soon American Journal of Respiratory and Critical Care Medicine. Jun, 2005 | Pubmed ID: 15914570 Heme Oxygenase-1: from Bench to Bedside American Journal of Respiratory and Critical Care Medicine. Sep, 2005 | Pubmed ID: 15901614 FLIP Protects Against Hypoxia/reoxygenation-induced Endothelial Cell Apoptosis by Inhibiting Bax Activation Molecular and Cellular Biology. Jun, 2005 | Pubmed ID: 15899875 Heme Oxygenase-1: Redox Regulation of a Stress Protein in Lung and Cell Culture Models Antioxidants & Redox Signaling. Jan-Feb, 2005 | Pubmed ID: 15650398 Carbon Monoxide Suppresses Bleomycin-induced Lung Fibrosis The American Journal of Pathology. Jan, 2005 | Pubmed ID: 15631997 Enhanced Nitric Oxide Production Associated with Airway Hyporesponsiveness in the Absence of IL-10 American Journal of Physiology. Lung Cellular and Molecular Physiology. May, 2005 | Pubmed ID: 15618456 Bcl-XL Disrupts Death-inducing Signal Complex Formation in Plasma Membrane Induced by Hypoxia/reoxygenation FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2004 | Pubmed ID: 15576486 Comprehensive Gene Expression Profiles Reveal Pathways Related to the Pathogenesis of Chronic Obstructive Pulmonary Disease Proceedings of the National Academy of Sciences of the United States of America. Oct, 2004 | Pubmed ID: 15469929 Carbon Monoxide Promotes Fas/CD95-induced Apoptosis in Jurkat Cells The Journal of Biological Chemistry. Oct, 2004 | Pubmed ID: 15280387 Caveolae Compartmentalization of Heme Oxygenase-1 in Endothelial Cells FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2004 | Pubmed ID: 15226268 Inhaled Carbon Monoxide Confers Antiinflammatory Effects Against Ventilator-induced Lung Injury American Journal of Respiratory and Critical Care Medicine. Sep, 2004 | Pubmed ID: 15142867 Carbon Monoxide: to Boldly Go Where NO Has Gone Before Science's STKE : Signal Transduction Knowledge Environment. Apr, 2004 | Pubmed ID: 15114002 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2004 | Pubmed ID: 15001560 Carbon Monoxide Inhibits T Lymphocyte Proliferation Via Caspase-dependent Pathway Journal of Immunology (Baltimore, Md. : 1950). Jan, 2004 | Pubmed ID: 14707100 Hepatocyte Growth Factor Protects Against Hypoxia/reoxygenation-induced Apoptosis in Endothelial Cells The Journal of Biological Chemistry. Feb, 2004 | Pubmed ID: 14625309 Carbon Monoxide Protects Against Liver Failure Through Nitric Oxide-induced Heme Oxygenase 1 The Journal of Experimental Medicine. Dec, 2003 | Pubmed ID: 14657222 Carbon Monoxide Inhalation Protects Rat Intestinal Grafts from Ischemia/reperfusion Injury The American Journal of Pathology. Oct, 2003 | Pubmed ID: 14507665 Heme Oxygenase-1 and Carbon Monoxide in Pulmonary Medicine Respiratory Research. 2003 | Pubmed ID: 12964953 Protective Effect of Carbon Monoxide Inhalation for Cold-preserved Small Intestinal Grafts Surgery. Aug, 2003 | Pubmed ID: 12947331 Pathways of Cell Signaling in Hyperoxia Free Radical Biology & Medicine. Aug, 2003 | Pubmed ID: 12899937 Low-dose Carbon Monoxide Reduces Airway Hyperresponsiveness in Mice American Journal of Physiology. Lung Cellular and Molecular Physiology. Dec, 2003 | Pubmed ID: 12896878 Suppression of Inflammatory Cytokine Production by Carbon Monoxide Involves the JNK Pathway and AP-1 The Journal of Biological Chemistry. Sep, 2003 | Pubmed ID: 12857751 Carbon Monoxide Induces Cytoprotection in Rat Orthotopic Lung Transplantation Via Anti-inflammatory and Anti-apoptotic Effects The American Journal of Pathology. Jul, 2003 | Pubmed ID: 12819027 Necrotic Cell Death in Response to Oxidant Stress Involves the Activation of the Apoptogenic Caspase-8/bid Pathway The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12754217 Deficiency in the C-Jun NH2-terminal Kinase Signaling Pathway Confers Susceptibility to Hyperoxic Lung Injury in Mice American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2003 | Pubmed ID: 12651633 Reactive Oxygen Species and Extracellular Signal-regulated Kinase 1/2 Mitogen-activated Protein Kinase Mediate Hyperoxia-induced Cell Death in Lung Epithelium American Journal of Respiratory Cell and Molecular Biology. Mar, 2003 | Pubmed ID: 12594056 Inhaled Carbon Monoxide Suppresses the Development of Postoperative Ileus in the Murine Small Intestine Gastroenterology. Feb, 2003 | Pubmed ID: 12557144 Carbon Monoxide Suppresses Arteriosclerotic Lesions Associated with Chronic Graft Rejection and with Balloon Injury Nature Medicine. Feb, 2003 | Pubmed ID: 12539038 Transcriptional Regulation of the HO-1 Gene in Cultured Macrophages Exposed to Model Airborne Particulate Matter American Journal of Physiology. Lung Cellular and Molecular Physiology. Mar, 2003 | Pubmed ID: 12456389 Carbon Monoxide Inhibition of Apoptosis During Ischemia-reperfusion Lung Injury is Dependent on the P38 Mitogen-activated Protein Kinase Pathway and Involves Caspase 3 The Journal of Biological Chemistry. Jan, 2003 | Pubmed ID: 12399465 American Journal of Physiology. Lung Cellular and Molecular Physiology. Jan, 2003 | Pubmed ID: 12388337 Carbon Monoxide Modulates Endotoxin-induced Production of Granulocyte Macrophage Colony-stimulating Factor in Macrophages American Journal of Respiratory Cell and Molecular Biology. Dec, 2002 | Pubmed ID: 12444034 Carbon Monoxide Inhibits Human Airway Smooth Muscle Cell Proliferation Via Mitogen-activated Protein Kinase Pathway American Journal of Respiratory Cell and Molecular Biology. Nov, 2002 | Pubmed ID: 12397020 TGF-beta1 Stimulates HO-1 Via the P38 Mitogen-activated Protein Kinase in A549 Pulmonary Epithelial Cells American Journal of Physiology. Lung Cellular and Molecular Physiology. Nov, 2002 | Pubmed ID: 12376363 Heme Oxygenase-1: Molecular Mechanisms of Gene Expression in Oxygen-related Stress Antioxidants & Redox Signaling. Aug, 2002 | Pubmed ID: 12230874 Mitogen Activated Protein Kinase (MAPK) Pathway Regulates Heme Oxygenase-1 Gene Expression by Hypoxia in Vascular Cells Antioxidants & Redox Signaling. Aug, 2002 | Pubmed ID: 12230870 Mitogen-activated Protein Kinases Regulate HO-1 Gene Transcription After Ischemia-reperfusion Lung Injury American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2002 | Pubmed ID: 12225959 Heme Oxygenase/carbon Monoxide Signaling Pathways: Regulation and Functional Significance Molecular and Cellular Biochemistry. May-Jun, 2002 | Pubmed ID: 12162441 Heme Oxygenase-1: the "emerging Molecule" Has Arrived American Journal of Respiratory Cell and Molecular Biology. Jul, 2002 | Pubmed ID: 12091240 Differential Modulation by Exogenous Carbon Monoxide of TNF-alpha Stimulated Mitogen-activated Protein Kinases in Rat Pulmonary Artery Endothelial Cells Antioxidants & Redox Signaling. Apr, 2002 | Pubmed ID: 12006175 Emerging Role of Carbon Monoxide in Physiologic and Pathophysiologic States Antioxidants & Redox Signaling. Apr, 2002 | Pubmed ID: 12006173 The Saga of Leucine Zippers Continues: in Response to Oxidative Stress American Journal of Respiratory Cell and Molecular Biology. Feb, 2002 | Pubmed ID: 11804863 Carbon Monoxide-dependent Signaling Critical Care Medicine. Jan, 2002 | Pubmed ID: 11782556 Carbon Monoxide-dependent Signaling Critical Care Medicine. Jan, 2001 | Pubmed ID: 11839940 Isolation of Mouse Respiratory Epithelial Cells and Exposure to Experimental Cigarette Smoke at Air Liquid Interface Hilaire C. Lam1,2, Augustine M.K. Choi1, Stefan W. Ryter1 1Department of Medicine, Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School, 2Cellular and Molecular Pathology, School of Medicine, University of Pittsburgh JoVE 2513 Medicina
Isolation of Mouse Respiratory Epithelial Cells and Exposure to Experimental Cigarette Smoke at Air Liquid Interface Hilaire C. Lam1,2, Augustine M.K. Choi1, Stefan W. Ryter1 1Department of Medicine, Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School, 2Cellular and Molecular Pathology, School of Medicine, University of Pittsburgh JoVE 2513 Medicina