Christopher Heeschen Stem Cells & Cancer Group, Molecular Pathology Program Spanish National Cancer Research Center Biography Publications Institution JoVE Articles Christopher Heeschen has not added a biography. If you are Christopher Heeschen and would like to personalize this page please email our Author Liaison for assistance. Publications The MiR-17-92 Cluster Counteracts Quiescence and Chemoresistance in a Distinct Subpopulation of Pancreatic Cancer Stem Cells Gut. Apr, 2015 | Pubmed ID: 25887381 Microenvironmental HCAP-18/LL-37 Promotes Pancreatic Ductal Adenocarcinoma by Activating Its Cancer Stem Cell Compartment Gut. Apr, 2015 | Pubmed ID: 25841238 Inhibition of CD47 Effectively Targets Pancreatic Cancer Stem Cells Via Dual Mechanisms Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2015 | Pubmed ID: 25717063 ISG15 is a Critical Microenvironmental Factor for Pancreatic Cancer Stem Cells Cancer Research. Dec, 2014 | Pubmed ID: 25368022 K-RasV14I Recapitulates Noonan Syndrome in Mice Proceedings of the National Academy of Sciences of the United States of America. Nov, 2014 | Pubmed ID: 25359213 Intracellular Autofluorescence: a Biomarker for Epithelial Cancer Stem Cells Nature Methods. Nov, 2014 | Pubmed ID: 25262208 Nicotine Promotes Initiation and Progression of KRAS-Induced Pancreatic Cancer Via Gata6-Dependent Dedifferentiation of Acinar Cells in Mice Gastroenterology. Nov, 2014 | Pubmed ID: 25127677 Chloroquine Targets Pancreatic Cancer Stem Cells Via Inhibition of CXCR4 and Hedgehog Signaling Molecular Cancer Therapeutics. Jul, 2014 | Pubmed ID: 24785258 Metformin Targets the Metabolic Achilles Heel of Human Pancreatic Cancer Stem Cells PloS One. 2013 | Pubmed ID: 24204632 Multimodal Treatment Eliminates Cancer Stem Cells and Leads to Long-Term Survival in Primary Human Pancreatic Cancer Tissue Xenografts PloS One. 2013 | Pubmed ID: 23825539 Standing out from the Crowd: Cancer Stem Cells in Hepatocellular Carcinoma Cancer Cell. Apr, 2013 | Pubmed ID: 23597561 Stem Cells & Pancreatic Cancer Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]. Mar-Apr, 2013 | Pubmed ID: 23561967 Aurora B Prevents Delayed DNA Replication and Premature Mitotic Exit by Repressing P21(Cip1) Cell Cycle (Georgetown, Tex.). Apr, 2013 | Pubmed ID: 23428904 Metastatic Cancer Stem Cells--quo Vadis? Clinical Chemistry. Aug, 2013 | Pubmed ID: 23288488 Immuno-targeting of Pancreatic Cancer Stem Cells: A New Therapeutic Strategy Against a Devastating Disease? Oncoimmunology. Jul, 2012 | Pubmed ID: 22754787 Pancreatic Stellate Cells Form a Niche for Cancer Stem Cells and Promote Their Self-renewal and Invasiveness Cell Cycle (Georgetown, Tex.). Apr, 2012 | Pubmed ID: 22421149 Vascular Incorporation of Endothelial Colony-forming Cells is Essential for Functional Recovery of Murine Ischemic Tissue Following Cell Therapy Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2012 | Pubmed ID: 22199368 Stem Cells As the Root of Pancreatic Ductal Adenocarcinoma Experimental Cell Research. Apr, 2012 | Pubmed ID: 22119145 EpCAM/CD3-Bispecific T-cell Engaging Antibody MT110 Eliminates Primary Human Pancreatic Cancer Stem Cells Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2012 | Pubmed ID: 22096026 Nodal/Activin Signaling Drives Self-renewal and Tumorigenicity of Pancreatic Cancer Stem Cells and Provides a Target for Combined Drug Therapy Cell Stem Cell. Nov, 2011 | Pubmed ID: 22056140 Pancreatic Cancer Stem Cells: New Insights and Perspectives Journal of Gastroenterology. Aug, 2011 | Pubmed ID: 21698355 Inhibition of Ataxia Telangiectasia- and Rad3-related Function Abrogates the in Vitro and in Vivo Tumorigenicity of Human Colon Cancer Cells Through Depletion of the CD133(+) Tumor-initiating Cell Fraction Stem Cells (Dayton, Ohio). Mar, 2011 | Pubmed ID: 21308861 Adiponectin Pretreatment Counteracts the Detrimental Effect of a Diabetic Environment on Endothelial Progenitors Diabetes. Feb, 2011 | Pubmed ID: 21270275 Combination of Injectable Multiple Growth Factor-releasing Scaffolds and Cell Therapy As an Advanced Modality to Enhance Tissue Neovascularization Arteriosclerosis, Thrombosis, and Vascular Biology. Oct, 2010 | Pubmed ID: 20689075 Pancreatic Cancer Stem Cells - Update and Future Perspectives Molecular Oncology. Oct, 2010 | Pubmed ID: 20580623 Cancer Stem Cells in Solid Tumors Seminars in Cancer Biology. Apr, 2010 | Pubmed ID: 20371287 Cancer Stem Cells As New Therapeutic Target to Prevent Tumour Progression and Metastasis Frontiers in Bioscience (Elite Edition). 2010 | Pubmed ID: 20036905 Pancreatic Cancer Stem Cells--insights and Perspectives Expert Opinion on Biological Therapy. Oct, 2009 | Pubmed ID: 19723015 Add Some Fat to Vascular Progenitor Cell Therapy Circulation Research. Jun, 2009 | Pubmed ID: 19542018 Combined Targeted Treatment to Eliminate Tumorigenic Cancer Stem Cells in Human Pancreatic Cancer Gastroenterology. Sep, 2009 | Pubmed ID: 19501590 CGMP-dependent Protein Kinase I is Crucial for Angiogenesis and Postnatal Vasculogenesis PloS One. 2009 | Pubmed ID: 19287493 Prostaglandin E Positively Modulates Endothelial Progenitor Cell Homeostasis: an Advanced Treatment Modality for Autologous Cell Therapy Journal of Vascular Research. 2009 | Pubmed ID: 19142013 The Wnt Antagonist Dickkopf-1 Mobilizes Vasculogenic Progenitor Cells Via Activation of the Bone Marrow Endosteal Stem Cell Niche Circulation Research. Oct, 2008 | Pubmed ID: 18776043 More Good Reasons for Adherence to Statin Therapy During Acute Coronary Syndromes European Heart Journal. Sep, 2008 | Pubmed ID: 18676969 Concentration of Bone Marrow Total Nucleated Cells by a Point-of-care Device Provides a High Yield and Preserves Their Functional Activity Cell Transplantation. 2008 | Pubmed ID: 18351022 Metastatic Cancer Stem Cells: a New Target for Anti-cancer Therapy? Cell Cycle (Georgetown, Tex.). Jan, 2008 | Pubmed ID: 18256530 Quantitation of Myocardial Borderzone Using Reconstructive 3-D Echocardiography After Chronic Infarction in Rats: Incremental Value of Low-dose Dobutamine Ultrasound in Medicine & Biology. Apr, 2008 | Pubmed ID: 17996357 Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic Cancer Cell Stem Cell. Sep, 2007 | Pubmed ID: 18371365 Genetically Engineered Stem Cells for Therapeutic Gene Delivery Current Gene Therapy. Aug, 2007 | Pubmed ID: 17969558 Nonbone Marrow-derived Endothelial Progenitor Cells: What is Their Exact Location? Circulation Research. Oct, 2007 | Pubmed ID: 17967790 Selective Functional Exhaustion of Hematopoietic Progenitor Cells in the Bone Marrow of Patients with Postinfarction Heart Failure Journal of the American College of Cardiology. Jun, 2007 | Pubmed ID: 17572250 Influence of Sample Type on Soluble CD40 Ligand Assessment in Patients with Acute Coronary Syndromes Thrombosis Research. 2007 | Pubmed ID: 17337289 Nonbone Marrow-derived Circulating Progenitor Cells Contribute to Postnatal Neovascularization Following Tissue Ischemia Circulation Research. Mar, 2007 | Pubmed ID: 17272807 The Immunosuppressant FTY720 Inhibits Tumor Angiogenesis Via the Sphingosine 1-phosphate Receptor 1 Journal of Cellular Biochemistry. May, 2007 | Pubmed ID: 17203465 Endothelial Progenitor Cells Participate in Nicotine-mediated Angiogenesis Journal of the American College of Cardiology. Dec, 2006 | Pubmed ID: 17174197 Low-energy Shock Wave for Enhancing Recruitment of Endothelial Progenitor Cells: a New Modality to Increase Efficacy of Cell Therapy in Chronic Hind Limb Ischemia Circulation. Dec, 2006 | Pubmed ID: 17145991 Ex Vivo Pretreatment of Bone Marrow Mononuclear Cells with Endothelial NO Synthase Enhancer AVE9488 Enhances Their Functional Activity for Cell Therapy Proceedings of the National Academy of Sciences of the United States of America. Sep, 2006 | Pubmed ID: 16983080 Effects of Granulocyte Colony Simulating Factor on Functional Activities of Endothelial Progenitor Cells in Patients with Chronic Ischemic Heart Disease Arteriosclerosis, Thrombosis, and Vascular Biology. Oct, 2006 | Pubmed ID: 16902165 Differential Effects of Short-term Lipid Lowering with Ezetimibe and Statins on Endothelial Function in Patients with CAD: Clinical Evidence for 'pleiotropic' Functions of Statin Therapy European Heart Journal. May, 2006 | Pubmed ID: 16621868 Influence of Sample Type and Storage Conditions on Soluble CD40 Ligand Assessment Clinical Chemistry. May, 2006 | Pubmed ID: 16527885 Elevated Placental Growth Factor Levels Are Associated with Adverse Outcomes at Four-year Follow-up in Patients with Acute Coronary Syndromes Journal of the American College of Cardiology. Jan, 2006 | Pubmed ID: 16412852 Biomarkers in Acute Coronary Syndromes and Their Role in Diabetic Patients Diabetes & Vascular Disease Research. Oct, 2005 | Pubmed ID: 16334593 Biochemical Monitoring of MTOR Inhibitor-based Immunosuppression Following Kidney Transplantation: a Novel Approach for Tailored Immunosuppressive Therapy Kidney International. Dec, 2005 | Pubmed ID: 16316335 Impaired CXCR4 Signaling Contributes to the Reduced Neovascularization Capacity of Endothelial Progenitor Cells from Patients with Coronary Artery Disease Circulation Research. Nov, 2005 | Pubmed ID: 16254213 Soluble Factors Released by Endothelial Progenitor Cells Promote Migration of Endothelial Cells and Cardiac Resident Progenitor Cells Journal of Molecular and Cellular Cardiology. Nov, 2005 | Pubmed ID: 16199052 Involvement of Foxo Transcription Factors in Angiogenesis and Postnatal Neovascularization The Journal of Clinical Investigation. Sep, 2005 | Pubmed ID: 16100571 Histone Deacetylase Activity is Essential for the Expression of HoxA9 and for Endothelial Commitment of Progenitor Cells The Journal of Experimental Medicine. Jun, 2005 | Pubmed ID: 15928198 Cathepsin L is Required for Endothelial Progenitor Cell-induced Neovascularization Nature Medicine. Feb, 2005 | Pubmed ID: 15665831 Pregnancy-associated Plasma Protein-A Levels in Patients with Acute Coronary Syndromes: Comparison with Markers of Systemic Inflammation, Platelet Activation, and Myocardial Necrosis Journal of the American College of Cardiology. Jan, 2005 | Pubmed ID: 15653020 Role of Beta2-integrins for Homing and Neovascularization Capacity of Endothelial Progenitor Cells The Journal of Experimental Medicine. Jan, 2005 | Pubmed ID: 15623573 N-terminal Pro-B-type Natriuretic Peptide Levels for Dynamic Risk Stratification of Patients with Acute Coronary Syndromes Circulation. Nov, 2004 | Pubmed ID: 15533869 The Pro-apoptotic Serum Activity is an Independent Mortality Predictor of Patients with Heart Failure European Heart Journal. Sep, 2004 | Pubmed ID: 15351161 The Role of NOS3 in Stem Cell Mobilization Trends in Molecular Medicine. Sep, 2004 | Pubmed ID: 15350893 Interleukin-10 Serum Levels and Systemic Endothelial Vasoreactivity in Patients with Coronary Artery Disease Journal of the American College of Cardiology. Jul, 2004 | Pubmed ID: 15234404 Inflammatory Markers and Coronary Artery Disease Current Opinion in Pharmacology. Apr, 2004 | Pubmed ID: 15063355 Profoundly Reduced Neovascularization Capacity of Bone Marrow Mononuclear Cells Derived from Patients with Chronic Ischemic Heart Disease Circulation. Apr, 2004 | Pubmed ID: 15037527 111In-labeled CD34+ Hematopoietic Progenitor Cells in a Rat Myocardial Infarction Model Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Mar, 2004 | Pubmed ID: 15001696 Quantitative Bedside Testing of Troponin T: is It Equal to Laboratory Testing? The Cardiac Reader Troponin T (CARE T) Study Clinical Laboratory. 2004 | Pubmed ID: 15000216 P21Cip1 Levels Differentially Regulate Turnover of Mature Endothelial Cells, Endothelial Progenitor Cells, and in Vivo Neovascularization Circulation Research. Mar, 2004 | Pubmed ID: 14752032 Prognostic Value of Placental Growth Factor in Patients with Acute Chest Pain JAMA. Jan, 2004 | Pubmed ID: 14747500 Relevance of Monocytic Features for Neovascularization Capacity of Circulating Endothelial Progenitor Cells Circulation. Nov, 2003 | Pubmed ID: 14581410 Essential Role of Endothelial Nitric Oxide Synthase for Mobilization of Stem and Progenitor Cells Nature Medicine. Nov, 2003 | Pubmed ID: 14556003 Second Hand Smoke Stimulates Tumor Angiogenesis and Growth Cancer Cell. Sep, 2003 | Pubmed ID: 14522253 Myeloperoxidase Serum Levels Predict Risk in Patients with Acute Coronary Syndromes Circulation. Sep, 2003 | Pubmed ID: 12952835 Erythropoietin is a Potent Physiologic Stimulus for Endothelial Progenitor Cell Mobilization Blood. Aug, 2003 | Pubmed ID: 12702503 Serum Level of the Antiinflammatory Cytokine Interleukin-10 is an Important Prognostic Determinant in Patients with Acute Coronary Syndromes Circulation. Apr, 2003 | Pubmed ID: 12668510 Soluble CD40 Ligand in Acute Coronary Syndromes The New England Journal of Medicine. Mar, 2003 | Pubmed ID: 12646667 Nicotine Promotes Arteriogenesis Journal of the American College of Cardiology. Feb, 2003 | Pubmed ID: 12575981 Nicotine Strongly Activates Dendritic Cell-mediated Adaptive Immunity: Potential Role for Progression of Atherosclerotic Lesions Circulation. Feb, 2003 | Pubmed ID: 12566374 Prognostic Significance of Angiogenic Growth Factor Serum Levels in Patients with Acute Coronary Syndromes Circulation. Feb, 2003 | Pubmed ID: 12566361 Withdrawal of Statins in Patients with Acute Coronary Syndromes Circulation. Jan, 2003 | Pubmed ID: 12551886 A Novel Angiogenic Pathway Mediated by Non-neuronal Nicotinic Acetylcholine Receptors The Journal of Clinical Investigation. Aug, 2002 | Pubmed ID: 12189247 Withdrawal of Statins Increases Event Rates in Patients with Acute Coronary Syndromes Circulation. Mar, 2002 | Pubmed ID: 11914253 Statins Have Biphasic Effects on Angiogenesis Circulation. Feb, 2002 | Pubmed ID: 11839631 Studeren alvleesklier- Stamcel Kenmerken voor het ontwikkelen van nieuwe behandelingsstrategieën Enza Lonardo1,2, Michele Cioffi1, Patricia Sancho1,3, Shanthini Crusz3, Christopher Heeschen1,3 1Stem Cells & Cancer Group, Molecular Pathology Program, Spanish National Cancer Research Center, 2Institute for Research in Biomedicine (IRB Barcelona), 3Center for Stem Cells in Cancer & Ageing, Barts Cancer Institute, Queen Mary University of London Medicina
Studeren alvleesklier- Stamcel Kenmerken voor het ontwikkelen van nieuwe behandelingsstrategieën Enza Lonardo1,2, Michele Cioffi1, Patricia Sancho1,3, Shanthini Crusz3, Christopher Heeschen1,3 1Stem Cells & Cancer Group, Molecular Pathology Program, Spanish National Cancer Research Center, 2Institute for Research in Biomedicine (IRB Barcelona), 3Center for Stem Cells in Cancer & Ageing, Barts Cancer Institute, Queen Mary University of London Medicina