David H. Wasserman Department of Molecular Physiology and Biophysics Vanderbilt University School of Medicine Biography Publications Institution JoVE Articles David H. Wasserman has not added a biography. If you are David H. Wasserman and would like to personalize this page please email our Author Liaison for assistance. Publications Disassociation of Muscle Insulin Signaling and Insulin-Stimulated Glucose Uptake During Endotoxemia PloS One. 2012 | Pubmed ID: 22276152 Overproduction of Angiotensinogen from Adipose Tissue Induces Adipose Inflammation, Glucose Intolerance, and Insulin Resistance Obesity (Silver Spring, Md.). Jan, 2012 | Pubmed ID: 21979391 Mesenchymal Stem Cell Transplantation for the Infarcted Heart: a Role in Minimizing Abnormalities in Cardiac-specific Energy Metabolism American Journal of Physiology. Endocrinology and Metabolism. Jan, 2012 | Pubmed ID: 21971524 Hepatic Glucagon Action is Essential for Exercise-induced Reversal of Mouse Fatty Liver Diabetes. Nov, 2011 | Pubmed ID: 21885872 Assessment of Different Bariatric Surgeries in the Treatment of Obesity and Insulin Resistance in Mice Annals of Surgery. Jul, 2011 | Pubmed ID: 21522012 Diet-induced Muscle Insulin Resistance is Associated with Extracellular Matrix Remodeling and Interaction with Integrin Alpha2beta1 in Mice Diabetes. Feb, 2011 | Pubmed ID: 21270253 Role of TAPP1 and TAPP2 Adaptor Binding to PtdIns(3,4)P2 in Regulating Insulin Sensitivity Defined by Knock-in Analysis The Biochemical Journal. Mar, 2011 | Pubmed ID: 21204784 Mice with AS160/TBC1D4-Thr649Ala Knockin Mutation Are Glucose Intolerant with Reduced Insulin Sensitivity and Altered GLUT4 Trafficking Cell Metabolism. Jan, 2011 | Pubmed ID: 21195350 The Physiological Regulation of Glucose Flux into Muscle in Vivo The Journal of Experimental Biology. Jan, 2011 | Pubmed ID: 21177945 Standard Operating Procedures for Describing and Performing Metabolic Tests of Glucose Homeostasis in Mice Disease Models & Mechanisms. Sep-Oct, 2010 | Pubmed ID: 20713647 Glucagon-like Peptide-1 Receptor Knockout Mice Are Protected from High-fat Diet-induced Insulin Resistance Endocrinology. Oct, 2010 | Pubmed ID: 20685876 Glucagon and Lipid Interactions in the Regulation of Hepatic AMPK Signaling and Expression of PPARalpha and FGF21 Transcripts in Vivo American Journal of Physiology. Endocrinology and Metabolism. Oct, 2010 | Pubmed ID: 20663988 Endothelial Nitric Oxide Synthase is Central to Skeletal Muscle Metabolic Regulation and Enzymatic Signaling During Exercise in Vivo American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. May, 2010 | Pubmed ID: 20200137 Circadian Clock Gene Bmal1 is Not Essential; Functional Replacement with Its Paralog, Bmal2 Current Biology : CB. Feb, 2010 | Pubmed ID: 20153195 Lost in Translation Diabetes. Sep, 2009 | Pubmed ID: 19720822 Hepatic Energy State is Regulated by Glucagon Receptor Signaling in Mice The Journal of Clinical Investigation. Aug, 2009 | Pubmed ID: 19662685 NIH Experiment in Centralized Mouse Phenotyping: the Vanderbilt Experience and Recommendations for Evaluating Glucose Homeostasis in the Mouse American Journal of Physiology. Endocrinology and Metabolism. Oct, 2009 | Pubmed ID: 19638507 Skeletal Muscle AMP-activated Protein Kinase is Essential for the Metabolic Response to Exercise in Vivo The Journal of Biological Chemistry. Sep, 2009 | Pubmed ID: 19525228 Fibroblast Growth Factor 21 Controls Glycemia Via Regulation of Hepatic Glucose Flux and Insulin Sensitivity Endocrinology. Sep, 2009 | Pubmed ID: 19470704 Mitochondrial H2O2 Emission and Cellular Redox State Link Excess Fat Intake to Insulin Resistance in Both Rodents and Humans The Journal of Clinical Investigation. Mar, 2009 | Pubmed ID: 19188683 The Glucagon-like Peptide-1 Receptor Regulates Endogenous Glucose Production and Muscle Glucose Uptake Independent of Its Incretin Action Endocrinology. Mar, 2009 | Pubmed ID: 19008308 Four Grams of Glucose American Journal of Physiology. Endocrinology and Metabolism. Jan, 2009 | Pubmed ID: 18840763 Metabolic Implications of Reduced Heart-type Fatty Acid Binding Protein in Insulin Resistant Cardiac Muscle Biochimica Et Biophysica Acta. Oct, 2008 | Pubmed ID: 18692568 Markers of Glycemic Control in the Mouse: Comparisons of 6-h- and Overnight-fasted Blood Glucoses to Hb A1c American Journal of Physiology. Endocrinology and Metabolism. Oct, 2008 | Pubmed ID: 18664598 Long Chain Fatty Acid Uptake in Vivo: Comparison of [125I]-BMIPP and [3H]-bromopalmitate Lipids. Aug, 2008 | Pubmed ID: 18481132 Glucose Metabolism in Vivo in Four Commonly Used Inbred Mouse Strains Diabetes. Jul, 2008 | Pubmed ID: 18398139 Insulin Action in the Double Incretin Receptor Knockout Mouse Diabetes. Feb, 2008 | Pubmed ID: 17977951 Phosphorylation Barriers to Skeletal and Cardiac Muscle Glucose Uptakes in High-fat Fed Mice: Studies in Mice with a 50% Reduction of Hexokinase II Diabetes. Oct, 2007 | Pubmed ID: 17639019 Glucose Kinetics and Exercise Tolerance in Mice Lacking the GLUT4 Glucose Transporter The Journal of Physiology. Jul, 2007 | Pubmed ID: 17495042 Chronic Treatment with Sildenafil Improves Energy Balance and Insulin Action in High Fat-fed Conscious Mice Diabetes. Apr, 2007 | Pubmed ID: 17229936 Point-Counterpoint: Glucose Phosphorylation Is/is Not a Significant Barrier to Muscle Glucose Uptake by the Working Muscle Journal of Applied Physiology (Bethesda, Md. : 1985). Dec, 2006 | Pubmed ID: 17106068 Physical Activity/exercise and Type 2 Diabetes: a Consensus Statement from the American Diabetes Association Diabetes Care. Jun, 2006 | Pubmed ID: 16732040 Considerations in the Design of Hyperinsulinemic-euglycemic Clamps in the Conscious Mouse Diabetes. Feb, 2006 | Pubmed ID: 16443772 Insulin Secretion in the Conscious Mouse is Biphasic and Pulsatile American Journal of Physiology. Endocrinology and Metabolism. Mar, 2006 | Pubmed ID: 16249252 Energy State of the Liver During Short-term and Exhaustive Exercise in C57BL/6J Mice American Journal of Physiology. Endocrinology and Metabolism. Mar, 2006 | Pubmed ID: 16219665 Plasminogen Activator Inhibitor-1 Modulates Adipocyte Differentiation American Journal of Physiology. Endocrinology and Metabolism. Jan, 2006 | Pubmed ID: 16144810 Individual Mice Can Be Distinguished by the Period of Their Islet Calcium Oscillations: is There an Intrinsic Islet Period That is Imprinted in Vivo? Diabetes. Dec, 2005 | Pubmed ID: 16306370 Partial Gene Deletion of Heart-type Fatty Acid-binding Protein Limits the Severity of Dietary-induced Insulin Resistance Diabetes. Nov, 2005 | Pubmed ID: 16249436 Mobilization of Glucose from the Liver During Exercise and Replenishment Afterward Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée. Jun, 2005 | Pubmed ID: 16129894 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside Renders Glucose Output by the Liver of the Dog Insensitive to a Pharmacological Increment in Insulin American Journal of Physiology. Endocrinology and Metabolism. Dec, 2005 | Pubmed ID: 16046457 Hexokinase II Protein Content is a Determinant of Exercise Endurance Capacity in the Mouse The Journal of Physiology. Jul, 2005 | Pubmed ID: 15878951 Interaction of Physiological Mechanisms in Control of Muscle Glucose Uptake Clinical and Experimental Pharmacology & Physiology. Apr, 2005 | Pubmed ID: 15810999 Portal Venous 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside Infusion Overcomes Hyperinsulinemic Suppression of Endogenous Glucose Output Diabetes. Feb, 2005 | Pubmed ID: 15677495 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside Causes Acute Hepatic Insulin Resistance in Vivo Diabetes. Feb, 2005 | Pubmed ID: 15677492 Glucoregulation During and After Exercise in Health and Insulin-dependent Diabetes Exercise and Sport Sciences Reviews. Jan, 2005 | Pubmed ID: 15640716 Control of Muscle Glucose Uptake: Test of the Rate-limiting Step Paradigm in Conscious, Unrestrained Mice The Journal of Physiology. Feb, 2005 | Pubmed ID: 15576451 Heart-type Fatty Acid-binding Protein Reciprocally Regulates Glucose and Fatty Acid Utilization During Exercise American Journal of Physiology. Endocrinology and Metabolism. Feb, 2005 | Pubmed ID: 15454399 Exercise-induced Changes in Insulin and Glucagon Are Not Required for Enhanced Hepatic Glucose Uptake After Exercise but Influence the Fate of Glucose Within the Liver Diabetes. Dec, 2004 | Pubmed ID: 15561932 Portal Vein Caffeine Infusion Enhances Net Hepatic Glucose Uptake During a Glucose Load in Conscious Dogs The Journal of Nutrition. Nov, 2004 | Pubmed ID: 15514273 Control of Exercise-stimulated Muscle Glucose Uptake by GLUT4 is Dependent on Glucose Phosphorylation Capacity in the Conscious Mouse The Journal of Biological Chemistry. Dec, 2004 | Pubmed ID: 15456776 Physical Activity/exercise and Type 2 Diabetes Diabetes Care. Oct, 2004 | Pubmed ID: 15451933 Portal Venous Hyperinsulinemia Does Not Stimulate Gut Glucose Absorption in the Conscious Dog Metabolism: Clinical and Experimental. Oct, 2004 | Pubmed ID: 15375784 Zonation of Labeling of Lipogenic Acetyl-CoA Across the Liver: Implications for Studies of Lipogenesis by Mass Isotopomer Analysis The Journal of Biological Chemistry. Oct, 2004 | Pubmed ID: 15284242 Regulation of Insulin-stimulated Muscle Glucose Uptake in the Conscious Mouse: Role of Glucose Transport is Dependent on Glucose Phosphorylation Capacity Endocrinology. Nov, 2004 | Pubmed ID: 15284204 AMPK Stimulation Increases LCFA but Not Glucose Clearance in Cardiac Muscle in Vivo American Journal of Physiology. Endocrinology and Metabolism. Nov, 2004 | Pubmed ID: 15265760 AMP Kinase-induced Skeletal Muscle Glucose but Not Long-chain Fatty Acid Uptake is Dependent on Nitric Oxide Diabetes. Jun, 2004 | Pubmed ID: 15161745 Hepatic Glucose Autoregulation: Responses to Small, Non-insulin-induced Changes in Arterial Glucose American Journal of Physiology. Endocrinology and Metabolism. Aug, 2004 | Pubmed ID: 15053988 Effect of Sex on Counterregulatory Responses to Exercise After Antecedent Hypoglycemia in Type 1 Diabetes American Journal of Physiology. Endocrinology and Metabolism. Jul, 2004 | Pubmed ID: 14998785 Prevention of Obesity and Insulin Resistance in Mice Lacking Plasminogen Activator Inhibitor 1 Diabetes. Feb, 2004 | Pubmed ID: 14747283 Hexokinase II Overexpression Improves Exercise-stimulated but Not Insulin-stimulated Muscle Glucose Uptake in High-fat-fed C57BL/6J Mice Diabetes. Feb, 2004 | Pubmed ID: 14747279 Suppression of Endogenous Glucose Production by Mild Hyperinsulinemia During Exercise is Determined Predominantly by Portal Venous Insulin Diabetes. Feb, 2004 | Pubmed ID: 14747277 Distributed Control of Glucose Uptake by Working Muscles of Conscious Mice: Roles of Transport and Phosphorylation American Journal of Physiology. Endocrinology and Metabolism. Jan, 2004 | Pubmed ID: 13129858 Quinides of Roasted Coffee Enhance Insulin Action in Conscious Rats The Journal of Nutrition. Nov, 2003 | Pubmed ID: 14608069 Regulation of Hepatic and Peripheral Glucose Disposal Best Practice & Research. Clinical Endocrinology & Metabolism. Sep, 2003 | Pubmed ID: 12962690 Interaction of Insulin and Prior Exercise in Control of Hepatic Metabolism of a Glucose Load Diabetes. Aug, 2003 | Pubmed ID: 12882903 Hexokinase II Partial Knockout Impairs Exercise-stimulated Glucose Uptake in Oxidative Muscles of Mice American Journal of Physiology. Endocrinology and Metabolism. Nov, 2003 | Pubmed ID: 12865258 Effect of Antecedent Hypoglycemia on Counterregulatory Responses to Subsequent Euglycemic Exercise in Type 1 Diabetes Diabetes. Jul, 2003 | Pubmed ID: 12829644 Prior Exercise Enhances Passive Absorption of Intraduodenal Glucose Journal of Applied Physiology (Bethesda, Md. : 1985). Sep, 2003 | Pubmed ID: 12740315 Fiber Type-specific Determinants of Vmax for Insulin-stimulated Muscle Glucose Uptake in Vivo American Journal of Physiology. Endocrinology and Metabolism. Mar, 2003 | Pubmed ID: 12556351 Transporter-mediated Absorption is the Primary Route of Entry and is Required for Passive Absorption of Intestinal Glucose into the Blood of Conscious Dogs The Journal of Nutrition. Jul, 2002 | Pubmed ID: 12097672 Contrasting Effects of Exercise and NOS Inhibition on Tissue-specific Fatty Acid and Glucose Uptake in Mice American Journal of Physiology. Endocrinology and Metabolism. Jul, 2002 | Pubmed ID: 12067851 Prevention of Overt Hypoglycemia During Exercise: Stimulation of Endogenous Glucose Production Independent of Hepatic Catecholamine Action and Changes in Pancreatic Hormone Concentration Diabetes. May, 2002 | Pubmed ID: 11978626 Prior Exercise and the Response to Insulin-induced Hypoglycemia in the Dog American Journal of Physiology. Endocrinology and Metabolism. May, 2002 | Pubmed ID: 11934679 Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice Julio E. Ayala1, Deanna P. Bracy2,3, Carlo Malabanan3, Freyja D. James2,3, Tasneem Ansari3, Patrick T. Fueger4, Owen P. McGuinness2,3, David H. Wasserman2,3 1Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute at Lake Nona, 2Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 3Vanderbilt Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, 4Department of Pediatrics and Cellular and Integrative Physiology, Indiana University School of Medicine JoVE 3188 Medicina
Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice Julio E. Ayala1, Deanna P. Bracy2,3, Carlo Malabanan3, Freyja D. James2,3, Tasneem Ansari3, Patrick T. Fueger4, Owen P. McGuinness2,3, David H. Wasserman2,3 1Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute at Lake Nona, 2Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 3Vanderbilt Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, 4Department of Pediatrics and Cellular and Integrative Physiology, Indiana University School of Medicine JoVE 3188 Medicina