Owen P. McGuinness Department of Molecular Physiology and Biophysics Vanderbilt University School of Medicine Biography Publications Institution JoVE Articles Owen P. McGuinness has not added a biography. If you are Owen P. McGuinness and would like to personalize this page please email our Author Liaison for assistance. Publications Adropin Deficiency is Associated with Increased Adiposity and Insulin Resistance Obesity (Silver Spring, Md.). Feb, 2012 | Pubmed ID: 22318315 Disassociation of Muscle Insulin Signaling and Insulin-Stimulated Glucose Uptake During Endotoxemia PloS One. 2012 | Pubmed ID: 22276152 Ablation of Ghrelin Receptor Reduces Adiposity and Improves Insulin Sensitivity During Aging by Regulating Fat Metabolism in White and Brown Adipose Tissues Aging Cell. Dec, 2011 | Pubmed ID: 21895961 Assessment of Different Bariatric Surgeries in the Treatment of Obesity and Insulin Resistance in Mice Annals of Surgery. Jul, 2011 | Pubmed ID: 21522012 Continuous Low-dose Fructose Infusion Does Not Reverse Glucagon-mediated Decrease in Hepatic Glucose Utilization Metabolism: Clinical and Experimental. Jun, 2011 | Pubmed ID: 20940071 Metabolic Response to Endotoxin in Vivo in the Conscious Mouse: Role of Interleukin-6 Metabolism: Clinical and Experimental. Jan, 2011 | Pubmed ID: 20102773 Standard Operating Procedures for Describing and Performing Metabolic Tests of Glucose Homeostasis in Mice Disease Models & Mechanisms. Sep-Oct, 2010 | Pubmed ID: 20713647 Advantages of Dynamic "closed Loop" Stable Isotope Flux Phenotyping over Static "open Loop" Clamps in Detecting Silent Genetic and Dietary Phenotypes Metabolomics : Official Journal of the Metabolomic Society. Jun, 2010 | Pubmed ID: 20445758 Impaired Glucose Tolerance and Predisposition to the Fasted State in Liver Glycogen Synthase Knock-out Mice The Journal of Biological Chemistry. Apr, 2010 | Pubmed ID: 20178984 Circadian Clock Gene Bmal1 is Not Essential; Functional Replacement with Its Paralog, Bmal2 Current Biology : CB. Feb, 2010 | Pubmed ID: 20153195 Lost in Translation Diabetes. Sep, 2009 | Pubmed ID: 19720822 NIH Experiment in Centralized Mouse Phenotyping: the Vanderbilt Experience and Recommendations for Evaluating Glucose Homeostasis in the Mouse American Journal of Physiology. Endocrinology and Metabolism. Oct, 2009 | Pubmed ID: 19638507 Skeletal Muscle AMP-activated Protein Kinase is Essential for the Metabolic Response to Exercise in Vivo The Journal of Biological Chemistry. Sep, 2009 | Pubmed ID: 19525228 Deletion of the Mouse Slc30a8 Gene Encoding Zinc Transporter-8 Results in Impaired Insulin Secretion The Biochemical Journal. Aug, 2009 | Pubmed ID: 19450229 Inactivation of NF-kappaB P50 Leads to Insulin Sensitization in Liver Through Post-translational Inhibition of P70S6K The Journal of Biological Chemistry. Jul, 2009 | Pubmed ID: 19433583 Insulin Signaling in Alpha Cells Modulates Glucagon Secretion in Vivo Cell Metabolism. Apr, 2009 | Pubmed ID: 19356716 Glucagon-mediated Impairments in Hepatic and Peripheral Tissue Nutrient Disposal Are Not Aggravated by Increased Lipid Availability American Journal of Physiology. Endocrinology and Metabolism. May, 2009 | Pubmed ID: 19208853 Macrophage TNF-alpha Contributes to Insulin Resistance and Hepatic Steatosis in Diet-induced Obesity American Journal of Physiology. Endocrinology and Metabolism. Sep, 2007 | Pubmed ID: 17578885 Point-counterpoint: Interleukin-6 Does/does Not Have a Beneficial Role in Insulin Sensitivity and Glucose Homeostasis Journal of Applied Physiology (Bethesda, Md. : 1985). Feb, 2007 | Pubmed ID: 17323468 Glucagon Chronically Impairs Hepatic and Muscle Glucose Disposal American Journal of Physiology. Endocrinology and Metabolism. Mar, 2007 | Pubmed ID: 17132827 Monoclonal Antibody Antagonists of Hypothalamic FGFR1 Cause Potent but Reversible Hypophagia and Weight Loss in Rodents and Monkeys American Journal of Physiology. Endocrinology and Metabolism. Mar, 2007 | Pubmed ID: 17132826 Deletion of the Gene Encoding the Ubiquitously Expressed Glucose-6-phosphatase Catalytic Subunit-related Protein (UGRP)/glucose-6-phosphatase Catalytic Subunit-beta Results in Lowered Plasma Cholesterol and Elevated Glucagon The Journal of Biological Chemistry. Dec, 2006 | Pubmed ID: 17023421 Impact of Portal Glucose Delivery on Glucose Metabolism in Conscious, Unrestrained Mice American Journal of Physiology. Endocrinology and Metabolism. Dec, 2006 | Pubmed ID: 16822956 Counterregulatory Deficits Occur Within 24 H of a Single Hypoglycemic Episode in Conscious, Unrestrained, Chronically Cannulated Mice American Journal of Physiology. Endocrinology and Metabolism. Apr, 2006 | Pubmed ID: 16533951 Glucocorticoid-deficient Corticotropin-releasing Hormone Knockout Mice Maintain Glucose Requirements but Not Autonomic Responses During Repeated Hypoglycemia American Journal of Physiology. Endocrinology and Metabolism. Jul, 2006 | Pubmed ID: 16449297 Considerations in the Design of Hyperinsulinemic-euglycemic Clamps in the Conscious Mouse Diabetes. Feb, 2006 | Pubmed ID: 16443772 Overexpression of the Insulin Receptor Inhibitor PC-1/ENPP1 Induces Insulin Resistance and Hyperglycemia American Journal of Physiology. Endocrinology and Metabolism. Apr, 2006 | Pubmed ID: 16278247 Insulin Secretion in the Conscious Mouse is Biphasic and Pulsatile American Journal of Physiology. Endocrinology and Metabolism. Mar, 2006 | Pubmed ID: 16249252 Individual Mice Can Be Distinguished by the Period of Their Islet Calcium Oscillations: is There an Intrinsic Islet Period That is Imprinted in Vivo? Diabetes. Dec, 2005 | Pubmed ID: 16306370 Suppression of Aging in Mice by the Hormone Klotho Science (New York, N.Y.). Sep, 2005 | Pubmed ID: 16123266 Defective Glucose Homeostasis During Infection Annual Review of Nutrition. 2005 | Pubmed ID: 16011457 Route-dependent Effect of Nutritional Support on Liver Glucose Uptake American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Nov, 2005 | Pubmed ID: 15994371 Impact of Continuous and Pulsatile Insulin Delivery on Net Hepatic Glucose Uptake American Journal of Physiology. Endocrinology and Metabolism. Aug, 2005 | Pubmed ID: 15755768 Control of Muscle Glucose Uptake: Test of the Rate-limiting Step Paradigm in Conscious, Unrestrained Mice The Journal of Physiology. Feb, 2005 | Pubmed ID: 15576451 Time Course of the Hepatic Adaptation to TPN: Interaction with Glycogen Depletion American Journal of Physiology. Endocrinology and Metabolism. Jan, 2005 | Pubmed ID: 15339746 Microfluidic Glucose Stimulation Reveals Limited Coordination of Intracellular Ca2+ Activity Oscillations in Pancreatic Islets Proceedings of the National Academy of Sciences of the United States of America. Aug, 2004 | Pubmed ID: 15317941 Prevention of Obesity and Insulin Resistance in Mice Lacking Plasminogen Activator Inhibitor 1 Diabetes. Feb, 2004 | Pubmed ID: 14747283 Impact of Infection on Glucose-dependent Liver Glucose Uptake During TPN: Interaction with Insulin American Journal of Physiology. Endocrinology and Metabolism. Feb, 2004 | Pubmed ID: 14532169 Effects of Fructose on Hepatic Glucose Metabolism Current Opinion in Clinical Nutrition and Metabolic Care. Jul, 2003 | Pubmed ID: 12806219 Infection Impairs Insulin-dependent Hepatic Glucose Uptake During Total Parenteral Nutrition American Journal of Physiology. Endocrinology and Metabolism. Mar, 2003 | Pubmed ID: 12441309 Impact of Chronic Fructose Infusion on Hepatic Metabolism During TPN Administration American Journal of Physiology. Endocrinology and Metabolism. Dec, 2002 | Pubmed ID: 12424103 Impact of Intraportal N(omega)-nitro-L-arginine Infusion on Hepatic Glucose Metabolism in Total Parenteral Nutrition-adapted Dogs: Interaction with Infection Metabolism: Clinical and Experimental. Mar, 2002 | Pubmed ID: 11887160 Physiological Consequences of Phasic Insulin Release in the Normal Animal Diabetes. Feb, 2002 | Pubmed ID: 11815467 Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice Julio E. Ayala1, Deanna P. Bracy2,3, Carlo Malabanan3, Freyja D. James2,3, Tasneem Ansari3, Patrick T. Fueger4, Owen P. McGuinness2,3, David H. Wasserman2,3 1Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute at Lake Nona, 2Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 3Vanderbilt Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, 4Department of Pediatrics and Cellular and Integrative Physiology, Indiana University School of Medicine JoVE 3188 Medicina
Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice Julio E. Ayala1, Deanna P. Bracy2,3, Carlo Malabanan3, Freyja D. James2,3, Tasneem Ansari3, Patrick T. Fueger4, Owen P. McGuinness2,3, David H. Wasserman2,3 1Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute at Lake Nona, 2Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 3Vanderbilt Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, 4Department of Pediatrics and Cellular and Integrative Physiology, Indiana University School of Medicine JoVE 3188 Medicina