David S. Warner Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology Duke University Biography Publications Institution JoVE Articles David S. Warner has not added a biography. If you are David S. Warner and would like to personalize this page please email our Author Liaison for assistance. Publications ApoE Mimetic Ameliorates Motor Deficit and Tissue Damage in Rat Spinal Cord Injury Journal of Neuroscience Research. Jul, 2014 | Pubmed ID: 24633884 Anesthetic Neuroprotection: Antecedents and An Appraisal of Preclinical and Clinical Data Quality Current Pharmaceutical Design. Feb, 2014 | Pubmed ID: 24502575 Volatile Anesthetic Sedation During Therapeutic Hypothermia After Cardiac Arrest in the ICU: a Journey of a Thousand Miles Begins with a Single Step Critical Care Medicine. Feb, 2014 | Pubmed ID: 24434469 Mr. Piano Man: Reflections on the Life of Physician, Scientist, and Humanitarian, William L. Young, MD (1954-2013) Journal of Neurosurgical Anesthesiology. Jan, 2014 | Pubmed ID: 24394583 Metalloporphyrins As Therapeutic Catalytic Oxidoreductants in Central Nervous System Disorders Antioxidants & Redox Signaling. May, 2014 | Pubmed ID: 23706004 Drowning Resuscitation Requires Another State of Mind Resuscitation. Nov, 2013 | Pubmed ID: 24036192 Differential Coordination Demands in Fe Versus Mn Water-soluble Cationic Metalloporphyrins Translate into Remarkably Different Aqueous Redox Chemistry and Biology Inorganic Chemistry. May, 2013 | Pubmed ID: 23646875 Protective Astrogenesis from the SVZ Niche After Injury is Controlled by Notch Modulator Thbs4 Nature. May, 2013 | Pubmed ID: 23615612 Comprehensive Pharmacokinetic Studies and Oral Bioavailability of Two Mn Porphyrin-based SOD Mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+ Free Radical Biology & Medicine. May, 2013 | Pubmed ID: 23328731 Design, Mechanism of Action, Bioavailability and Therapeutic Effects of Mn Porphyrin-based Redox Modulators Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre. 2013 | Pubmed ID: 23075911 Lack of Evidence for a Remote Effect of Renal Ischemia/reperfusion Acute Kidney Injury on Outcome from Temporary Focal Cerebral Ischemia in the Rat Journal of Cardiothoracic and Vascular Anesthesia. Feb, 2013 | Pubmed ID: 22841525 Xenon Neuroprotection in Experimental Stroke: Interactions with Hypothermia and Intracerebral Hemorrhage Anesthesiology. Dec, 2012 | Pubmed ID: 23143806 Brain Resuscitation in the Drowning Victim Neurocritical Care. Dec, 2012 | Pubmed ID: 22956050 A New SOD Mimic, Mn(III) Ortho N-butoxyethylpyridylporphyrin, Combines Superb Potency and Lipophilicity with Low Toxicity Free Radical Biology & Medicine. May, 2012 | Pubmed ID: 22336516 Statins Improve Outcome in Murine Models of Intracranial Hemorrhage and Traumatic Brain Injury: A Translational Approach Journal of Neurotrauma. Jan, 2012 | Pubmed ID: 22233347 Neuroprotective Efficacy from a Lipophilic Redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: Rodent Models of Ischemic Stroke and Subarachnoid Hemorrhage The Journal of Pharmacology and Experimental Therapeutics. Sep, 2011 | Pubmed ID: 21652782 Methoxy-derivatization of Alkyl Chains Increases the in Vivo Efficacy of Cationic Mn Porphyrins. Synthesis, Characterization, SOD-like Activity, and SOD-deficient E. Coli Study of Meta Mn(III) N-methoxyalkylpyridylporphyrins Dalton Transactions (Cambridge, England : 2003). Apr, 2011 | Pubmed ID: 21384047 Pharmacologically Augmented S-nitrosylated Hemoglobin Improves Recovery from Murine Subarachnoid Hemorrhage Stroke; a Journal of Cerebral Circulation. Feb, 2011 | Pubmed ID: 21193749 Adenosine-induced Transient Asystole for Intracranial Aneurysm Surgery: a Retrospective Review Journal of Neurosurgical Anesthesiology. Jan, 2011 | Pubmed ID: 20706138 Development of a Simplified Spinal Cord Ischemia Model in Mice Journal of Neuroscience Methods. Jun, 2010 | Pubmed ID: 20394775 Metalloporphyrin Antioxidants Ameliorate Normal Tissue Radiation Damage in Rat Brain International Journal of Radiation Biology. Feb, 2010 | Pubmed ID: 20148700 Simvastatin Treatment Duration and Cognitive Preservation in Experimental Subarachnoid Hemorrhage Journal of Neurosurgical Anesthesiology. Oct, 2009 | Pubmed ID: 19955895 Long-term Neuroprotection from a Potent Redox-modulating Metalloporphyrin in the Rat Free Radical Biology & Medicine. Oct, 2009 | Pubmed ID: 19631268 Oxygen and Glucose Deprivation in an Organotypic Hippocampal Slice Model of the Developing Rat Brain: the Effects on N-methyl-D-aspartate Subunit Composition Anesthesia and Analgesia. Jul, 2009 | Pubmed ID: 19535712 Drowning: a Cry for Help Anesthesiology. Jun, 2009 | Pubmed ID: 19417605 Effect of Lipophilicity of Mn (III) Ortho N-alkylpyridyl- and Diortho N, N'-diethylimidazolylporphyrins in Two In-vitro Models of Oxygen and Glucose Deprivation-induced Neuronal Death Free Radical Research. Apr, 2009 | Pubmed ID: 19259881 Perioperative Hypothermia: Use and Therapeutic Implications Journal of Neurotrauma. Mar, 2009 | Pubmed ID: 19231924 Filling in the Blanks Anesthesiology. Jan, 2009 | Pubmed ID: 19104163 2008 in Review: Advancing Medicine in Anesthesiology Anesthesiology. Dec, 2008 | Pubmed ID: 19034092 The Use of S100B As a Biomarker in Subarachnoid Hemorrhage: Clarity in Its Promise and Limits Critical Care Medicine. Aug, 2008 | Pubmed ID: 18664797 Long-term Cognitive Dysfunction Following Experimental Subarachnoid Hemorrhage: New Perspectives Experimental Neurology. Oct, 2008 | Pubmed ID: 18625221 Cerebral Ischemia/stroke and Small Ubiquitin-like Modifier (SUMO) Conjugation--a New Target for Therapeutic Intervention? Journal of Neurochemistry. Aug, 2008 | Pubmed ID: 18410505 Transient Focal Cerebral Ischemia Induces a Dramatic Activation of Small Ubiquitin-like Modifier Conjugation Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. May, 2008 | Pubmed ID: 18167501 Statins in Acute Brain Injury: Getting the Cart Before the Horse Neurocritical Care. 2008 | Pubmed ID: 18094941 Preclinical Models of Intracerebral Hemorrhage: a Translational Perspective Neurocritical Care. 2008 | Pubmed ID: 18058257 Transient Global Cerebral Ischemia Induces a Massive Increase in Protein Sumoylation Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Feb, 2008 | Pubmed ID: 17565359 Hypertonic Saline for Craniotomy? Anesthesiology. Nov, 2007 | Pubmed ID: 18073540 Simvastatin and Atorvastatin Improve Behavioral Outcome, Reduce Hippocampal Degeneration, and Improve Cerebral Blood Flow After Experimental Traumatic Brain Injury Experimental Neurology. Jul, 2007 | Pubmed ID: 17521631 Superparamagnetic Iron Oxide Labeling and Transplantation of Adipose-derived Stem Cells in Middle Cerebral Artery Occlusion-injured Mice AJR. American Journal of Roentgenology. Apr, 2007 | Pubmed ID: 17377054 Isoflurane Provides Long-term Protection Against Focal Cerebral Ischemia in the Rat Anesthesiology. Jan, 2007 | Pubmed ID: 17197850 Dissociation Between Vasospasm and Functional Improvement in a Murine Model of Subarachnoid Hemorrhage Neurosurgical Focus. 2006 | Pubmed ID: 17029343 NMDA-induced Apoptosis in Mixed Neuronal/glial Cortical Cell Cultures: the Effects of Isoflurane and Dizocilpine Journal of Neurosurgical Anesthesiology. Oct, 2006 | Pubmed ID: 17006121 Levetiracetam is Neuroprotective in Murine Models of Closed Head Injury and Subarachnoid Hemorrhage Neurocritical Care. 2006 | Pubmed ID: 16960300 Selective Gamma-aminobutyric Acid Type A Receptor Antagonism Reverses Isoflurane Ischemic Neuroprotection Anesthesiology. Jul, 2006 | Pubmed ID: 16809998 Cardiac Glycosides Provide Neuroprotection Against Ischemic Stroke: Discovery by a Brain Slice-based Compound Screening Platform Proceedings of the National Academy of Sciences of the United States of America. Jul, 2006 | Pubmed ID: 16793926 Induction of Hypothermia After Intraoperative Hypoxic Brain Insult Anesthesia and Analgesia. Jul, 2006 | Pubmed ID: 16790649 Changing Outcome from Aneurysmal Subarachnoid Hemorrhage: Another Step Closer Anesthesiology. Apr, 2006 | Pubmed ID: 16571953 A Novel ApoE-derived Therapeutic Reduces Vasospasm and Improves Outcome in a Murine Model of Subarachnoid Hemorrhage Neurocritical Care. 2006 | Pubmed ID: 16498192 A Comparison of Hyperbaric Oxygen Versus Hypoxic Cerebral Preconditioning in Neonatal Rats Brain Research. Feb, 2006 | Pubmed ID: 16458861 Effects of a Manganese (III) Porphyrin Catalytic Antioxidant in a Mouse Closed Head Injury Model European Journal of Pharmacology. Feb, 2006 | Pubmed ID: 16455070 The Effect of Age on Sciatic Nerve Block Duration Anesthesia and Analgesia. Feb, 2006 | Pubmed ID: 16428567 Peripheral Nerve Block Techniques for Ambulatory Surgery Anesthesia and Analgesia. Dec, 2005 | Pubmed ID: 16301239 Magnesium Neuroprotection is Limited in Humans with Acute Brain Injury Neurocritical Care. 2005 | Pubmed ID: 16159086 Isoflurane-induced Neuronal Degeneration: an Evaluation in Organotypic Hippocampal Slice Cultures Anesthesia and Analgesia. Sep, 2005 | Pubmed ID: 16115969 Simvastatin Reduces Vasospasm After Aneurysmal Subarachnoid Hemorrhage: Results of a Pilot Randomized Clinical Trial Stroke; a Journal of Cerebral Circulation. Sep, 2005 | Pubmed ID: 16051891 A Retrospective Analysis of a Remifentanil/propofol General Anesthetic for Craniotomy Before Awake Functional Brain Mapping Anesthesia and Analgesia. Aug, 2005 | Pubmed ID: 16037168 Intrathecal Administration of a Novel ApoE-derived Therapeutic Peptide Improves Outcome Following Perinatal Hypoxic-ischemic Injury Neuroscience Letters. Jun, 2005 | Pubmed ID: 15896489 Analysis of the Brain Bioavailability of Peripherally Administered Magnesium Sulfate: A Study in Humans with Acute Brain Injury Undergoing Prolonged Induced Hypermagnesemia Critical Care Medicine. Mar, 2005 | Pubmed ID: 15753761 A Novel Therapeutic Derived from Apolipoprotein E Reduces Brain Inflammation and Improves Outcome After Closed Head Injury Experimental Neurology. Mar, 2005 | Pubmed ID: 15698624 Apoptosis is Not Enhanced in Primary Mixed Neuronal/glial Cultures Protected by Isoflurane Against N-methyl-D-aspartate Excitotoxicity Anesthesia and Analgesia. Dec, 2004 | Pubmed ID: 15562059 Anesthetics Provide Limited but Real Protection Against Acute Brain Injury Journal of Neurosurgical Anesthesiology. Oct, 2004 | Pubmed ID: 15557838 Changes in Magnetization Transfer MRI Correlate with Spreading Depression-induced Astroglial Reactivity and Increased Protein Expression in Mice AJR. American Journal of Roentgenology. Dec, 2004 | Pubmed ID: 15547231 Treatment of Traumatic Brain Injury: One Size Does Not Fit All Anesthesia and Analgesia. Oct, 2004 | Pubmed ID: 15385377 Intraischemic Nitrous Oxide Alters Neither Neurologic nor Histologic Outcome: a Comparison with Dizocilpine Anesthesia and Analgesia. Sep, 2004 | Pubmed ID: 15333428 Oxidants, Antioxidants and the Ischemic Brain The Journal of Experimental Biology. Aug, 2004 | Pubmed ID: 15299043 Mouse Spinal Cord Compression Injury is Ameliorated by Intrathecal Cationic Manganese(III) Porphyrin Catalytic Antioxidant Therapy Neuroscience Letters. Aug, 2004 | Pubmed ID: 15276251 A No-laminectomy Spinal Cord Compression Injury Model in Mice Journal of Neurotrauma. May, 2004 | Pubmed ID: 15165367 Effects of Isoflurane Versus Fentanyl-nitrous Oxide Anesthesia on Long-term Outcome from Severe Forebrain Ischemia in the Rat Anesthesiology. May, 2004 | Pubmed ID: 15114213 Perioperative Neuroprotection: Are We Asking the Right Questions? Anesthesia and Analgesia. Mar, 2004 | Pubmed ID: 14980898 Pharmacologic Protection from Ischemic Neuronal Injury Journal of Neurosurgical Anesthesiology. Jan, 2004 | Pubmed ID: 14676578 Apolipoprotein E Protects Against Oxidative Stress in Mixed Neuronal-glial Cell Cultures by Reducing Glutamate Toxicity Neurochemistry International. Jan, 2004 | Pubmed ID: 12971913 Severe Hypotension is Not Essential for Isoflurane Neuroprotection Against Forebrain Ischemia in Mice Anesthesiology. Nov, 2003 | Pubmed ID: 14576552 Altered Perceptions After Upper and Lower Extremity Blocks: an Initial Investigation Regional Anesthesia and Pain Medicine. Sep-Oct, 2003 | Pubmed ID: 14556134 The Neuroprotective Effect of Xenon Administration During Transient Middle Cerebral Artery Occlusion in Mice Anesthesiology. Oct, 2003 | Pubmed ID: 14508320 APOE Genotype and an ApoE-mimetic Peptide Modify the Systemic and Central Nervous System Inflammatory Response The Journal of Biological Chemistry. Dec, 2003 | Pubmed ID: 14507923 Gamma-Aminobutyric Acid-A Receptors Contribute to Isoflurane Neuroprotection in Organotypic Hippocampal Cultures Anesthesia and Analgesia. Aug, 2003 | Pubmed ID: 12873954 The Difficulties of Ambulatory Interscalene and Intra-articular Infusions for Rotator Cuff Surgery: a Preliminary Report Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie. Mar, 2003 | Pubmed ID: 12620950 Possible Role for Vascular Cell Proliferation in Cerebral Vasospasm After Subarachnoid Hemorrhage Stroke; a Journal of Cerebral Circulation. Feb, 2003 | Pubmed ID: 12574555 Catalytic Antioxidants As Novel Pharmacologic Approaches to Treatment of Ischemic Brain Injury Drug News & Perspectives. Dec, 2002 | Pubmed ID: 12677251 Hemodynamic Effects of Metalloporphyrin Catalytic Antioxidants: Structure-activity Relationships and Species Specificity Free Radical Biology & Medicine. Dec, 2002 | Pubmed ID: 12488134 A Comparison of the Remifentanil and Fentanyl Adverse Effect Profile in a Multicenter Phase IV Study Journal of Clinical Anesthesia. Nov, 2002 | Pubmed ID: 12477583 Simvastatin Increases Endothelial Nitric Oxide Synthase and Ameliorates Cerebral Vasospasm Resulting from Subarachnoid Hemorrhage Stroke; a Journal of Cerebral Circulation. Dec, 2002 | Pubmed ID: 12468796 Apolipoprotein E Protects Against NMDA Excitotoxicity Neurobiology of Disease. Oct, 2002 | Pubmed ID: 12460559 Serum Von Willebrand Factor, Matrix Metalloproteinase-9, and Vascular Endothelial Growth Factor Levels Predict the Onset of Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage Neurosurgery. Nov, 2002 | Pubmed ID: 12383357 A Catalytic Antioxidant (AEOL 10150) Attenuates Expression of Inflammatory Genes in Stroke Free Radical Biology & Medicine. Oct, 2002 | Pubmed ID: 12374626 Paravertebral Somatic Nerve Block Compared with Peripheral Nerve Blocks for Outpatient Inguinal Herniorrhaphy Regional Anesthesia and Pain Medicine. Sep-Oct, 2002 | Pubmed ID: 12373694 Effects of Metalloporphyrin Catalytic Antioxidants in Experimental Brain Ischemia Free Radical Biology & Medicine. Oct, 2002 | Pubmed ID: 12361805 Attenuation of Cerebral Vasospasm After Subarachnoid Hemorrhage in Mice Overexpressing Extracellular Superoxide Dismutase Stroke; a Journal of Cerebral Circulation. Sep, 2002 | Pubmed ID: 12215605 Brain Oxygenation and Energy Metabolism: Part I-biological Function and Pathophysiology Neurosurgery. Aug, 2002 | Pubmed ID: 12182767 Allopregnanolone Attenuates N-methyl-D-aspartate-induced Excitotoxicity and Apoptosis in the Human NT2 Cell Line in Culture Neuroscience Letters. Aug, 2002 | Pubmed ID: 12123853 Mouse Model of Subarachnoid Hemorrhage Associated Cerebral Vasospasm: Methodological Analysis Neurological Research. Jul, 2002 | Pubmed ID: 12117325 Differential Cerebral Gene Expression During Cardiopulmonary Bypass in the Rat: Evidence for Apoptosis? Anesthesia and Analgesia. Jun, 2002 | Pubmed ID: 12031994 Pharmacological Correction of Hypothermic P(50) Shift Does Not Alter Outcome from Focal Cerebral Ischemia in Rats American Journal of Physiology. Heart and Circulatory Physiology. May, 2002 | Pubmed ID: 11959653 A Randomized, Double-blind Comparison of Ondansetron Versus Placebo for Prevention of Nausea and Vomiting After Infratentorial Craniotomy Journal of Neurosurgical Anesthesiology. Apr, 2002 | Pubmed ID: 11907389 Apolipoprotein E Affects the Central Nervous System Response to Injury and the Development of Cerebral Edema Annals of Neurology. Jan, 2002 | Pubmed ID: 11782990 Peripheral Nerve Blockade with Long-acting Local Anesthetics: a Survey of the Society for Ambulatory Anesthesia Anesthesia and Analgesia. Jan, 2002 | Pubmed ID: 11772803 Ambulatory Discharge After Long-acting Peripheral Nerve Blockade: 2382 Blocks with Ropivacaine Anesthesia and Analgesia. Jan, 2002 | Pubmed ID: 11772802 Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage Beilei Lei1, Huaxin Sheng1, Haichen Wang2, Christopher D. Lascola3, David S. Warner1,4, Daniel T. Laskowitz1,2,4, Michael L. James1,2 1Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University, 2Department of Neurology, Duke University, 3Department of Radiology, Duke University, 4Department of Neurobiology, Duke University JoVE 51439 Medicina
Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage Beilei Lei1, Huaxin Sheng1, Haichen Wang2, Christopher D. Lascola3, David S. Warner1,4, Daniel T. Laskowitz1,2,4, Michael L. James1,2 1Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University, 2Department of Neurology, Duke University, 3Department of Radiology, Duke University, 4Department of Neurobiology, Duke University JoVE 51439 Medicina