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Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage
 

Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage

Article DOI: 10.3791/51439-v • 09:41 min • July 3rd, 2014
July 3rd, 2014 •
1, 1, 2, 3, 1,4, 1,2,4, 1,2
1Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University, 2Department of Neurology, Duke University, 3Department of Radiology, Duke University, 4Department of Neurobiology, Duke University

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Automatic Translation

Preclinical models of intracerebral hemorrhage are utilized to mimic certain aspects of clinical disease. Thus, mechanisms of injury and potential therapeutic strategies may be explored. In this protocol, two models of intracerebral hemorrhage are described, intrastriatal (basal ganglia) injections of autologous blood or collagenase.

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Keywords: Intracerebral Hemorrhage Murine Models Intrastriatal Injection Autologous Blood Clostridial Collagenase Cerebrovascular Disease Neuroinflammation Cerebral Edema Neurobehavioral Outcomes Therapeutic Interventions
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