Ferry Ossendorp Department of Immunohematology and Blood Transfusion Leiden University Medical Center Biography Publications Institution JoVE Articles Ferry Ossendorp has not added a biography. If you are Ferry Ossendorp and would like to personalize this page please email our Author Liaison for assistance. Publications Cationic Synthetic Long Peptides-loaded Nanogels: An Efficient Therapeutic Vaccine Formulation for Induction of T-cell Responses Journal of Controlled Release : Official Journal of the Controlled Release Society. Dec, 2019 | Pubmed ID: 31672626 A Poly-neoantigen DNA Vaccine Synergizes with PD-1 Blockade to Induce T Cell-mediated Tumor Control Oncoimmunology. 2019 | Pubmed ID: 31646082 Effective Chemoimmunotherapy by Co-delivery of Doxorubicin and Immune Adjuvants in Biodegradable Nanoparticles Theranostics. 2019 | Pubmed ID: 31588231 PD-L1 Blockade Engages Tumor-infiltrating Lymphocytes to Co-express Targetable Activating and Inhibitory Receptors Journal for Immunotherapy of Cancer. Aug, 2019 | Pubmed ID: 31412943 Combined Inhibition of TGF-β Signaling and the PD-L1 Immune Checkpoint Is Differentially Effective in Tumor Models Cells. 04, 2019 | Pubmed ID: 30959852 Peptides Conjugated to 2-alkoxy-8-oxo-adenine As Potential Synthetic Vaccines Triggering TLR7 Bioorganic & Medicinal Chemistry Letters. Jun, 2019 | Pubmed ID: 30952595 Dual Synthetic Peptide Conjugate Vaccine Simultaneously Triggers TLR2 and NOD2 and Activates Human Dendritic Cells Bioconjugate Chemistry. Apr, 2019 | Pubmed ID: 30865430 FcγR Interaction is Not Required for Effective Anti-PD-L1 Immunotherapy but Can Add Additional Benefit Depending on the Tumor Model International Journal of Cancer. 01, 2019 | Pubmed ID: 30259976 A Dual-Color Bioluminescence Reporter Mouse for Simultaneous Imaging of T Cell Localization and Function Frontiers in Immunology. 2018 | Pubmed ID: 30671062 Novel TLR2-binding Adjuvant Induces Enhanced T Cell Responses and Tumor Eradication Journal for Immunotherapy of Cancer. 12, 2018 | Pubmed ID: 30541631 Tumor-draining Lymph Nodes Are Pivotal in PD-1/PD-L1 Checkpoint Therapy JCI Insight. 12, 2018 | Pubmed ID: 30518694 : A Workflow for Visual and Quantitative Analysis of Flow and Mass Cytometry Data to Discover Immune Signatures and Correlations Computational and Structural Biotechnology Journal. 2018 | Pubmed ID: 30450167 High FcγR Expression on Intratumoral Macrophages Enhances Tumor-Targeting Antibody Therapy Journal of Immunology (Baltimore, Md. : 1950). 12, 2018 | Pubmed ID: 30397036 FcγRI Expression on Macrophages is Required for Antibody-mediated Tumor Protection by Cytomegalovirus-based Vaccines Oncotarget. Jun, 2018 | Pubmed ID: 30034625 Combinatory Therapy Adopting Nanoparticle-based Cancer Vaccination with Immune Checkpoint Blockade for Treatment of Post-surgical Tumor Recurrences Journal of Controlled Release : Official Journal of the Controlled Release Society. 09, 2018 | Pubmed ID: 30008371 Approaches to Improve Chemically Defined Synthetic Peptide Vaccines Frontiers in Immunology. 2018 | Pubmed ID: 29755468 Formation of Immune Complexes with a Tetanus-Derived B Cell Epitope Boosts Human T Cell Responses to Covalently Linked Peptides in an Ex Vivo Blood Loop System Journal of Immunology (Baltimore, Md. : 1950). 07, 2018 | Pubmed ID: 29752315 Chemical Control over T-Cell Activation in Vivo Using Deprotection of Trans-Cyclooctene-Modified Epitopes ACS Chemical Biology. 06, 2018 | Pubmed ID: 29733186 Sustained Cross-presentation Capacity of Murine Splenic Dendritic Cell Subsets in Vivo European Journal of Immunology. 07, 2018 | Pubmed ID: 29676785 A Restricted Role for FcγR in the Regulation of Adaptive Immunity Journal of Immunology (Baltimore, Md. : 1950). 04, 2018 | Pubmed ID: 29523656 Linking T Cell Epitopes to a Common Linear B Cell Epitope: A Targeting and Adjuvant Strategy to Improve T Cell Responses Molecular Immunology. 01, 2018 | Pubmed ID: 29175591 Photodynamic-Immune Checkpoint Therapy Eradicates Local and Distant Tumors by CD8 T Cells Cancer Immunology Research. 10, 2017 | Pubmed ID: 28851692 PD-L1 Immune Suppression in Cancer: Tumor Cells or Host Cells? Oncoimmunology. 2017 | Pubmed ID: 28811961 CD4 T Cell and NK Cell Interplay Key to Regression of MHC Class I Tumors Upon TLR7/8 Agonist Therapy Cancer Immunology Research. 08, 2017 | Pubmed ID: 28637878 PD-L1 Expression on Malignant Cells is No Prerequisite for Checkpoint Therapy Oncoimmunology. 2017 | Pubmed ID: 28507803 C1q-Dependent Dendritic Cell Cross-Presentation of In Vivo-Formed Antigen-Antibody Complexes Journal of Immunology (Baltimore, Md. : 1950). 06, 2017 | Pubmed ID: 28432146 Self-Assembling Peptide Epitopes As Novel Platform for Anticancer Vaccination Molecular Pharmaceutics. 05, 2017 | Pubmed ID: 28088862 Strong in Vivo Antitumor Responses Induced by an Antigen Immobilized in Nanogels Via Reducible Bonds Nanoscale. Dec, 2016 | Pubmed ID: 27748778 The Optimization of Bioorthogonal Epitope Ligation Within MHC-I Complexes ACS Chemical Biology. 11, 2016 | Pubmed ID: 27704768 TLR2 Ligand-synthetic Long Peptide Conjugates Effectively Stimulate Tumor-draining Lymph Node T Cells of Cervical Cancer Patients Oncotarget. Oct, 2016 | Pubmed ID: 27564262 Glycan Modification of Antigen Alters Its Intracellular Routing in Dendritic Cells, Promoting Priming of T Cells ELife. Mar, 2016 | Pubmed ID: 26999763 Vaccines for Established Cancer: Overcoming the Challenges Posed by Immune Evasion Nature Reviews. Cancer. Apr, 2016 | Pubmed ID: 26965076 TAP-independent Self-peptides Enhance T Cell Recognition of Immune-escaped Tumors The Journal of Clinical Investigation. Feb, 2016 | Pubmed ID: 26784543 Combination of Photodynamic Therapy and Specific Immunotherapy Efficiently Eradicates Established Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2016 | Pubmed ID: 26546617 The Viral Context Instructs the Redundancy of Costimulatory Pathways in Driving CD8(+) T Cell Expansion ELife. Aug, 2015 | Pubmed ID: 26263500 Therapeutic Cancer Vaccines The Journal of Clinical Investigation. Sep, 2015 | Pubmed ID: 26214521 Polymeric Microparticles for Sustained and Local Delivery of AntiCD40 and AntiCTLA-4 in Immunotherapy of Cancer Biomaterials. Aug, 2015 | Pubmed ID: 25993015 The Translocon Protein Sec61 Mediates Antigen Transport from Endosomes in the Cytosol for Cross-presentation to CD8(+) T Cells Immunity. May, 2015 | Pubmed ID: 25979419 Polymeric Nanoparticles for Co-delivery of Synthetic Long Peptide Antigen and Poly IC As Therapeutic Cancer Vaccine Formulation Journal of Controlled Release : Official Journal of the Controlled Release Society. Apr, 2015 | Pubmed ID: 25660830 Vaccine-induced Tumor Necrosis Factor-producing T Cells Synergize with Cisplatin to Promote Tumor Cell Death Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2015 | Pubmed ID: 25501579 CD40-targeted Dendritic Cell Delivery of PLGA-nanoparticle Vaccines Induce Potent Anti-tumor Responses Biomaterials. Feb, 2015 | Pubmed ID: 25465442 Near-infrared Labeled, Ovalbumin Loaded Polymeric Nanoparticles Based on a Hydrophilic Polyester As Model Vaccine: In Vivo Tracking and Evaluation of Antigen-specific CD8(+) T Cell Immune Response Biomaterials. Jan, 2015 | Pubmed ID: 25453974 Two in One: Improving Synthetic Long Peptide Vaccines by Combining Antigen and Adjuvant in One Molecule Oncoimmunology. 2014 | Pubmed ID: 25610736 FcRγ-chain ITAM Signaling is Critically Required for Cross-presentation of Soluble Antibody-antigen Complexes by Dendritic Cells Journal of Immunology (Baltimore, Md. : 1950). Dec, 2014 | Pubmed ID: 25355925 Enhanced Cross-presentation and Improved CD8+ T Cell Responses After Mannosylation of Synthetic Long Peptides in Mice PloS One. 2014 | Pubmed ID: 25137039 Targeting Nanoparticles to CD40, DEC-205 or CD11c Molecules on Dendritic Cells for Efficient CD8(+) T Cell Response: a Comparative Study Journal of Controlled Release : Official Journal of the Controlled Release Society. Oct, 2014 | Pubmed ID: 25068703 Dominant Contribution of the Proteasome and Metalloproteinases to TAP-independent MHC-I Peptide Repertoire Molecular Immunology. Nov, 2014 | Pubmed ID: 24983205 Ovalbumin-coated PH-sensitive Microneedle Arrays Effectively Induce Ovalbumin-specific Antibody and T-cell Responses in Mice European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. Oct, 2014 | Pubmed ID: 24820032 IgG-mediated Anaphylaxis to a Synthetic Long Peptide Vaccine Containing a B Cell Epitope Can Be Avoided by Slow-release Formulation Journal of Immunology (Baltimore, Md. : 1950). Jun, 2014 | Pubmed ID: 24813207 Effectiveness of Slow-release Systems in CD40 Agonistic Antibody Immunotherapy of Cancer Vaccine. Mar, 2014 | Pubmed ID: 24508038 Local Immunomodulation for Cancer Therapy: Providing Treatment Where Needed Oncoimmunology. Nov, 2013 | Pubmed ID: 24490127 New Role of Signal Peptide Peptidase to Liberate C-terminal Peptides for MHC Class I Presentation Journal of Immunology (Baltimore, Md. : 1950). Oct, 2013 | Pubmed ID: 24048903 Dendritic Cells Process Synthetic Long Peptides Better Than Whole Protein, Improving Antigen Presentation and T-cell Activation European Journal of Immunology. Oct, 2013 | Pubmed ID: 23836147 Controlled Local Delivery of CTLA-4 Blocking Antibody Induces CD8+ T-cell-dependent Tumor Eradication and Decreases Risk of Toxic Side Effects Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2013 | Pubmed ID: 23788581 Prospects of Combinatorial Synthetic Peptide Vaccine-based Immunotherapy Against Cancer Seminars in Immunology. Apr, 2013 | Pubmed ID: 23706598 Efficient Ex Vivo Induction of T Cells with Potent Anti-tumor Activity by Protein Antigen Encapsulated in Nanoparticles Cancer Immunology, Immunotherapy : CII. Jul, 2013 | Pubmed ID: 23613147 Vaccine-induced Effector-memory CD8+ T Cell Responses Predict Therapeutic Efficacy Against Tumors Journal of Immunology (Baltimore, Md. : 1950). Oct, 2012 | Pubmed ID: 22914049 Fcγ Receptor IIb Strongly Regulates Fcγ Receptor-facilitated T Cell Activation by Dendritic Cells Journal of Immunology (Baltimore, Md. : 1950). Jul, 2012 | Pubmed ID: 22649202 Circulating Specific Antibodies Enhance Systemic Cross-priming by Delivery of Complexed Antigen to Dendritic Cells in Vivo European Journal of Immunology. Mar, 2012 | Pubmed ID: 22488363 The Inhibiting Fc Receptor for IgG, FcγRIIB, is a Modifier of Autoimmune Susceptibility Journal of Immunology (Baltimore, Md. : 1950). Aug, 2011 | Pubmed ID: 21724994 Discovery of Low-affinity Preproinsulin Epitopes and Detection of Autoreactive CD8 T-cells Using Combinatorial MHC Multimers Journal of Autoimmunity. Nov, 2011 | Pubmed ID: 21636247 Improved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC Vectors PloS One. Feb, 2011 | Pubmed ID: 21347234 Antigen Processing by Nardilysin and Thimet Oligopeptidase Generates Cytotoxic T Cell Epitopes Nature Immunology. Jan, 2011 | Pubmed ID: 21151101 Activity-based Profiling Reveals Reactivity of the Murine Thymoproteasome-specific Subunit Beta5t Chemistry & Biology. Aug, 2010 | Pubmed ID: 20797608 Effective CD8(+) T Cell Priming and Tumor Protection by Enterotoxin B Subunit-conjugated Peptides Targeted to Dendritic Cells Vaccine. Aug, 2009 | Pubmed ID: 19576942 DC-induced CD8(+) T-cell Response is Inhibited by MHC Class II-dependent DX5(+)CD4(+) Treg European Journal of Immunology. Jul, 2009 | Pubmed ID: 19544486 Antigen Storage Compartments in Mature Dendritic Cells Facilitate Prolonged Cytotoxic T Lymphocyte Cross-priming Capacity Proceedings of the National Academy of Sciences of the United States of America. Apr, 2009 | Pubmed ID: 19346487 Steric Hindrance and Fast Dissociation Explain the Lack of Immunogenicity of the Minor Histocompatibility HA-1Arg Null Allele Journal of Immunology (Baltimore, Md. : 1950). Apr, 2009 | Pubmed ID: 19342659 A Novel Role of Complement Factor C1q in Augmenting the Presentation of Antigen Captured in Immune Complexes to CD8+ T Lymphocytes Journal of Immunology (Baltimore, Md. : 1950). Jun, 2007 | Pubmed ID: 17548593 Dendritic Cells, but Not Macrophages or B Cells, Activate Major Histocompatibility Complex Class II-restricted CD4+ T Cells Upon Immune-complex Uptake in Vivo Immunology. Dec, 2006 | Pubmed ID: 16995881 Immune Complex-loaded Dendritic Cells Are Superior to Soluble Immune Complexes As Antitumor Vaccine Journal of Immunology (Baltimore, Md. : 1950). Apr, 2006 | Pubmed ID: 16585547 Selective Cytotoxic T-lymphocyte Targeting of Tumor Immune Escape Variants Nature Medicine. Apr, 2006 | Pubmed ID: 16550190 Murine Fc Receptors for IgG Are Redundant in Facilitating Presentation of Immune Complex Derived Antigen to CD8+ T Cells in Vivo Molecular Immunology. May, 2006 | Pubmed ID: 16513171 Autoreactive CD8 T Cells Associated with Beta Cell Destruction in Type 1 Diabetes Proceedings of the National Academy of Sciences of the United States of America. Dec, 2005 | Pubmed ID: 16339897 Differential Expression Regulation of the Alpha and Beta Subunits of the PA28 Proteasome Activator in Mature Dendritic Cells Journal of Immunology (Baltimore, Md. : 1950). Jun, 2005 | Pubmed ID: 15944286 Gamma Irradiation or CD4+-T-cell Depletion Causes Reactivation of Latent Salmonella Enterica Serovar Typhimurium Infection in C3H/HeN Mice Infection and Immunity. May, 2005 | Pubmed ID: 15845491 New Chelation Strategy Allows for Quick and Clean 99mTc-labeling of Synthetic Peptides Nuclear Medicine and Biology. Aug, 2004 | Pubmed ID: 15246374 Prolongation of Skin Graft Survival by Modulation of the Alloimmune Response with Alternatively Activated Dendritic Cells Transplantation. Dec, 2003 | Pubmed ID: 14702533 The Minor Histocompatibility Antigen HA-3 Arises from Differential Proteasome-mediated Cleavage of the Lymphoid Blast Crisis (Lbc) Oncoprotein Blood. Jul, 2003 | Pubmed ID: 12663445 Effective Therapeutic Anticancer Vaccines Based on Precision Guiding of Cytolytic T Lymphocytes Immunological Reviews. Oct, 2002 | Pubmed ID: 12445291 Antitumor Efficacy of Wild-type P53-specific CD4(+) T-helper Cells Cancer Research. Nov, 2002 | Pubmed ID: 12414646 Identification of a Novel HLA-B60-restricted T Cell Epitope of the Minor Histocompatibility Antigen HA-1 Locus Journal of Immunology (Baltimore, Md. : 1950). Sep, 2002 | Pubmed ID: 12218130 Antigen-antibody Immune Complexes Empower Dendritic Cells to Efficiently Prime Specific CD8+ CTL Responses in Vivo Journal of Immunology (Baltimore, Md. : 1950). Mar, 2002 | Pubmed ID: 11859111 Reorganization of Multivesicular Bodies Regulates MHC Class II Antigen Presentation by Dendritic Cells The Journal of Cell Biology. Oct, 2001 | Pubmed ID: 11581285 Expression of the Serpin Serine Protease Inhibitor 6 Protects Dendritic Cells from Cytotoxic T Lymphocyte-induced Apoptosis: Differential Modulation by T Helper Type 1 and Type 2 Cells The Journal of Experimental Medicine. Sep, 2001 | Pubmed ID: 11535633 Efficient Identification of Novel HLA-A(*)0201-presented Cytotoxic T Lymphocyte Epitopes in the Widely Expressed Tumor Antigen PRAME by Proteasome-mediated Digestion Analysis The Journal of Experimental Medicine. Jan, 2001 | Pubmed ID: 11136822 Differential Influence on Cytotoxic T Lymphocyte Epitope Presentation by Controlled Expression of Either Proteasome Immunosubunits or PA28 The Journal of Experimental Medicine. Aug, 2000 | Pubmed ID: 10952718 Immature Dendritic Cells Acquire CD8(+) Cytotoxic T Lymphocyte Priming Capacity Upon Activation by T Helper Cell-independent or -dependent Stimuli The Journal of Experimental Medicine. Jul, 2000 | Pubmed ID: 10880536 CD4 T Cells and Their Role in Antitumor Immune Responses The Journal of Experimental Medicine. Mar, 1999 | Pubmed ID: 10049938 Specific T Helper Cell Requirement for Optimal Induction of Cytotoxic T Lymphocytes Against Major Histocompatibility Complex Class II Negative Tumors The Journal of Experimental Medicine. Mar, 1998 | Pubmed ID: 9480979 Visualizzazione e quantificazione dei dati di citometria ad alta dimensione utilizzando Cytofast e i metodi di clustering a monte FlowSOM e Cytosplore Guillaume Beyrend1, Koen Stam2, Ferry Ossendorp1, Ramon Arens1 1Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2Department of Parasitology, Leiden University Medical Center JoVE 60525 Imunologia e Infecção
Visualizzazione e quantificazione dei dati di citometria ad alta dimensione utilizzando Cytofast e i metodi di clustering a monte FlowSOM e Cytosplore Guillaume Beyrend1, Koen Stam2, Ferry Ossendorp1, Ramon Arens1 1Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2Department of Parasitology, Leiden University Medical Center JoVE 60525 Imunologia e Infecção