Ramon Arens Department of Immunohematology and Blood Transfusion Leiden University Medical Center Biography Publications Institution JoVE Articles Ramon Arens has not added a biography. If you are Ramon Arens and would like to personalize this page please email our Author Liaison for assistance. Publications A Poly-neoantigen DNA Vaccine Synergizes with PD-1 Blockade to Induce T Cell-mediated Tumor Control Oncoimmunology. 2019 | Pubmed ID: 31646082 PD-L1 Blockade Engages Tumor-infiltrating Lymphocytes to Co-express Targetable Activating and Inhibitory Receptors Journal for Immunotherapy of Cancer. Aug, 2019 | Pubmed ID: 31412943 CD8+ T Cells Protect During Vein Graft Disease Development Frontiers in Cardiovascular Medicine. 2019 | Pubmed ID: 31263704 The Hallmarks of CMV-specific CD8 T-cell Differentiation Medical Microbiology and Immunology. Aug, 2019 | Pubmed ID: 30989333 Peripheral and Systemic Antigens Elicit an Expandable Pool of Resident Memory CD8 T Cells in the Bone Marrow European Journal of Immunology. Jun, 2019 | Pubmed ID: 30891737 T Cell Co-stimulation and Co-inhibition in Cardiovascular Disease: a Double-edged Sword Nature Reviews. Cardiology. Jun, 2019 | Pubmed ID: 30770894 Demarcated Thresholds of Tumor-specific CD8 T Cells Elicited by MCMV-based Vaccine Vectors Provide Robust Correlates of Protection Journal for Immunotherapy of Cancer. 01, 2019 | Pubmed ID: 30704520 Science Immunology. 12, 2018 | Pubmed ID: 30552101 : A Workflow for Visual and Quantitative Analysis of Flow and Mass Cytometry Data to Discover Immune Signatures and Correlations Computational and Structural Biotechnology Journal. 2018 | Pubmed ID: 30450167 Cytomegalovirus Infection and Progressive Differentiation of Effector-memory T Cells F1000Research. 2018 | Pubmed ID: 30345004 OX40 Stimulation Enhances Protective Immune Responses Induced After Vaccination With Attenuated Malaria Parasites Frontiers in Cellular and Infection Microbiology. 2018 | Pubmed ID: 30073152 FcγRI Expression on Macrophages is Required for Antibody-mediated Tumor Protection by Cytomegalovirus-based Vaccines Oncotarget. Jun, 2018 | Pubmed ID: 30034625 Impact of Congenital Cytomegalovirus Infection on Transcriptomes from Archived Dried Blood Spots in Relation to Long-term Clinical Outcome PloS One. 2018 | Pubmed ID: 30024899 A Flexible MHC Class I Multimer Loading System for Large-scale Detection of Antigen-specific T Cells The Journal of Experimental Medicine. 05, 2018 | Pubmed ID: 29666167 Features of Effective T Cell-Inducing Vaccines Against Chronic Viral Infections Frontiers in Immunology. 2018 | Pubmed ID: 29503649 Exhaustion and Inflation at Antipodes of T Cell Responses to Chronic Virus Infection Trends in Microbiology. 06, 2018 | Pubmed ID: 29249600 Human Plasmacytoid Dendritic Cells Acquire Phagocytic Capacity by TLR9 Ligation in the Presence of Soluble Factors Produced by Renal Epithelial Cells Kidney International. 02, 2018 | Pubmed ID: 29061332 The Contribution of Cytomegalovirus Infection to Immune Senescence Is Set by the Infectious Dose Frontiers in Immunology. 2017 | Pubmed ID: 29367854 CMV Immune Evasion and Manipulation of the Immune System with Aging GeroScience. 06, 2017 | Pubmed ID: 28647908 CD4 T Cell and NK Cell Interplay Key to Regression of MHC Class I Tumors Upon TLR7/8 Agonist Therapy Cancer Immunology Research. 08, 2017 | Pubmed ID: 28637878 Inhibition of 14q32 MicroRNA MiR-495 Reduces Lesion Formation, Intimal Hyperplasia and Plasma Cholesterol Levels in Experimental Restenosis Atherosclerosis. 06, 2017 | Pubmed ID: 28445809 Enforced OX40 Stimulation Empowers Booster Vaccines to Induce Effective CD4 and CD8 T Cell Responses Against Mouse Cytomegalovirus Infection Frontiers in Immunology. 2017 | Pubmed ID: 28265272 The Importance of Correctly Timing Cancer Immunotherapy Expert Opinion on Biological Therapy. 01, 2017 | Pubmed ID: 27802061 Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors PLoS Pathogens. Dec, 2016 | Pubmed ID: 27977791 Wnt Signaling As Master Regulator of T-Lymphocyte Responses: Implications for Transplant Therapy Transplantation. Dec, 2016 | Pubmed ID: 27861287 Improving Adoptive T Cell Therapy: The Particular Role of T Cell Costimulation, Cytokines, and Post-Transfer Vaccination Frontiers in Immunology. 2016 | Pubmed ID: 27656185 The Breadth of Synthetic Long Peptide Vaccine-Induced CD8+ T Cell Responses Determines the Efficacy Against Mouse Cytomegalovirus Infection PLoS Pathogens. 09, 2016 | Pubmed ID: 27637068 Tumor Eradication by Cisplatin Is Sustained by CD80/86-Mediated Costimulation of CD8+ T Cells Cancer Research. 10, 2016 | Pubmed ID: 27569212 Vaccination During Myeloid Cell Depletion by Cancer Chemotherapy Fosters Robust T Cell Responses Science Translational Medicine. Apr, 2016 | Pubmed ID: 27075626 Vaccines for Established Cancer: Overcoming the Challenges Posed by Immune Evasion Nature Reviews. Cancer. Apr, 2016 | Pubmed ID: 26965076 Viral Persistence Induces Antibody Inflation Without Altering Antibody Avidity Journal of Virology. May, 2016 | Pubmed ID: 26889035 In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity Immunity. Feb, 2016 | Pubmed ID: 26872694 Murine Cytomegalovirus (CMV) Infection Via the Intranasal Route Offers a Robust Model of Immunity Upon Mucosal CMV Infection The Journal of General Virology. Jan, 2016 | Pubmed ID: 26555192 Cytomegalovirus- and Epstein-Barr Virus-Induced T-Cell Expansions in Young Children Do Not Impair Naive T-cell Populations or Vaccination Responses: The Generation R Study The Journal of Infectious Diseases. Jan, 2016 | Pubmed ID: 26142434 The Quantity of Autocrine IL-2 Governs the Expansion Potential of CD8+ T Cells Journal of Immunology (Baltimore, Md. : 1950). Nov, 2015 | Pubmed ID: 26453748 Abatacept Decreases Disease Activity in a Absence of CD4(+) T Cells in a Collagen-induced Arthritis Model Arthritis Research & Therapy. Aug, 2015 | Pubmed ID: 26290328 The Viral Context Instructs the Redundancy of Costimulatory Pathways in Driving CD8(+) T Cell Expansion ELife. Aug, 2015 | Pubmed ID: 26263500 Therapeutic Cancer Vaccines The Journal of Clinical Investigation. Sep, 2015 | Pubmed ID: 26214521 New Approaches in Vaccine-based Immunotherapy for Human Papillomavirus-induced Cancer Current Opinion in Immunology. Aug, 2015 | Pubmed ID: 26001120 Therapeutic Peptide Vaccine-Induced CD8 T Cells Strongly Modulate Intratumoral Macrophages Required for Tumor Regression Cancer Immunology Research. Sep, 2015 | Pubmed ID: 25888578 5(th) International Workshop on CMV and Immunosenescence - A Shadow of Cytomegalovirus Infection on Immunological Memory European Journal of Immunology. Apr, 2015 | Pubmed ID: 25857239 Enhanced CD8 T Cell Responses Through GITR-mediated Costimulation Resolve Chronic Viral Infection PLoS Pathogens. Mar, 2015 | Pubmed ID: 25738498 CD55 Deposited on Synovial Collagen Fibers Protects from Immune Complex-mediated Arthritis Arthritis Research & Therapy. Jan, 2015 | Pubmed ID: 25596646 Vaccine-induced Tumor Necrosis Factor-producing T Cells Synergize with Cisplatin to Promote Tumor Cell Death Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2015 | Pubmed ID: 25501579 The Activation of the Adaptive Immune System: Cross-talk Between Antigen-presenting Cells, T Cells and B Cells Immunology Letters. Dec, 2014 | Pubmed ID: 25455596 T Cell Factor 1 Represses CD8+ Effector T Cell Formation and Function Journal of Immunology (Baltimore, Md. : 1950). Dec, 2014 | Pubmed ID: 25355919 Enhanced Cross-presentation and Improved CD8+ T Cell Responses After Mannosylation of Synthetic Long Peptides in Mice PloS One. 2014 | Pubmed ID: 25137039 New Advances in CMV and Immunosenescence Experimental Gerontology. Jul, 2014 | Pubmed ID: 24703889 Viral Inoculum Dose Impacts Memory T-cell Inflation European Journal of Immunology. Apr, 2014 | Pubmed ID: 24356925 Local Immunomodulation for Cancer Therapy: Providing Treatment Where Needed Oncoimmunology. Nov, 2013 | Pubmed ID: 24490127 Nodular Inflammatory Foci Are Sites of T Cell Priming and Control of Murine Cytomegalovirus Infection in the Neonatal Lung PLoS Pathogens. 2013 | Pubmed ID: 24348257 The Distinct Role of T Cell Costimulation in Antiviral Immunity Current Opinion in Virology. Aug, 2013 | Pubmed ID: 23850168 Lysine Acetyltransferase PCAF is a Key Regulator of Arteriogenesis Arteriosclerosis, Thrombosis, and Vascular Biology. Aug, 2013 | Pubmed ID: 23788761 Controlled Local Delivery of CTLA-4 Blocking Antibody Induces CD8+ T-cell-dependent Tumor Eradication and Decreases Risk of Toxic Side Effects Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2013 | Pubmed ID: 23788581 Prospects of Combinatorial Synthetic Peptide Vaccine-based Immunotherapy Against Cancer Seminars in Immunology. Apr, 2013 | Pubmed ID: 23706598 CD27-CD70 Costimulation Controls T Cell Immunity During Acute and Persistent Cytomegalovirus Infection Journal of Virology. Jun, 2013 | Pubmed ID: 23576505 Predicting the Efficacy of Cancer Vaccines by Evaluating T-cell Responses Oncoimmunology. Jan, 2013 | Pubmed ID: 23482345 Vaccine-induced Effector-memory CD8+ T Cell Responses Predict Therapeutic Efficacy Against Tumors Journal of Immunology (Baltimore, Md. : 1950). Oct, 2012 | Pubmed ID: 22914049 Polyfunctional CD4+ T Cell Responses to Immunodominant Epitopes Correlate with Disease Activity of Virulent Salmonella PloS One. 2012 | Pubmed ID: 22912884 Rational Design of Vaccines: Learning from Immune Evasion Mechanisms of Persistent Viruses and Tumors Advances in Immunology. 2012 | Pubmed ID: 22449784 Local Activation of CD8 T Cells and Systemic Tumor Eradication Without Toxicity Via Slow Release and Local Delivery of Agonistic CD40 Antibody Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2011 | Pubmed ID: 21389097 Differential B7-CD28 Costimulatory Requirements for Stable and Inflationary Mouse Cytomegalovirus-specific Memory CD8 T Cell Populations Journal of Immunology (Baltimore, Md. : 1950). Apr, 2011 | Pubmed ID: 21357256 Immunotherapy for Persistent Viral Infections and Associated Disease Trends in Immunology. Mar, 2011 | Pubmed ID: 21227751 Visualizzazione e quantificazione dei dati di citometria ad alta dimensione utilizzando Cytofast e i metodi di clustering a monte FlowSOM e Cytosplore Guillaume Beyrend1, Koen Stam2, Ferry Ossendorp1, Ramon Arens1 1Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2Department of Parasitology, Leiden University Medical Center JoVE 60525 Imunologia e Infecção
Visualizzazione e quantificazione dei dati di citometria ad alta dimensione utilizzando Cytofast e i metodi di clustering a monte FlowSOM e Cytosplore Guillaume Beyrend1, Koen Stam2, Ferry Ossendorp1, Ramon Arens1 1Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2Department of Parasitology, Leiden University Medical Center JoVE 60525 Imunologia e Infecção