Wing-Hon Lai Cardiology Division, Department of Medicine, Queen Mary Hospital University of Hong Kong Biography Publications Institution JoVE Articles Wing-Hon Lai has not added a biography. If you are Wing-Hon Lai and would like to personalize this page please email our Author Liaison for assistance. Publications Expression of Lmna-R225X Nonsense Mutation Results in Dilated Cardiomyopathy and Conduction Disorders (DCM-CD) in Mice: Impact of Exercise Training International Journal of Cardiology. 01, 2020 | Pubmed ID: 31668660 Catheter-Based Splanchnic Denervation for Treatment of Hypertensive Cardiomyopathy Hypertension (Dallas, Tex. : 1979). 07, 2019 | Pubmed ID: 31132949 Potent Immunomodulation and Angiogenic Effects of Mesenchymal Stem Cells Versus Cardiomyocytes Derived from Pluripotent Stem Cells for Treatment of Heart Failure Stem Cell Research & Therapy. 03, 2019 | Pubmed ID: 30845990 Empagliflozin Ammeliorates High Glucose Induced-Cardiac Dysfuntion in Human IPSC-Derived Cardiomyocytes Scientific Reports. 10, 2018 | Pubmed ID: 30291295 Improvement of Myocardial Function Following Catheter-Based Renal Denervation in Heart Failure JACC. Basic to Translational Science. Jun, 2017 | Pubmed ID: 30062148 Modeling Treatment Response for Lamin A/C Related Dilated Cardiomyopathy in Human Induced Pluripotent Stem Cells Journal of the American Heart Association. Jul, 2017 | Pubmed ID: 28754655 An Abnormal TRPV4-related Cytosolic Ca Rise in Response to Uniaxial Stretch in Induced Pluripotent Stem Cells-derived Cardiomyocytes from Dilated Cardiomyopathy Patients Biochimica Et Biophysica Acta. Nov, 2017 | Pubmed ID: 28754452 Correction of Hirschsprung-Associated Mutations in Human Induced Pluripotent Stem Cells Via Clustered Regularly Interspaced Short Palindromic Repeats/Cas9, Restores Neural Crest Cell Function Gastroenterology. 07, 2017 | Pubmed ID: 28342760 Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells Stem Cell Reports. 03, 2017 | Pubmed ID: 28262545 Lysosomal Membrane Permeabilization is Involved in Oxidative Stress-induced Apoptotic Cell Death in LAMP2-deficient IPSCs-derived Cerebral Cortical Neurons Biochemistry and Biophysics Reports. Mar, 2016 | Pubmed ID: 28955840 Amelioration of X-Linked Related Autophagy Failure in Danon Disease With DNA Methylation Inhibitor Circulation. Nov, 2016 | Pubmed ID: 27678261 Recent Advances in Animal and Human Pluripotent Stem Cell Modeling of Cardiac Laminopathy Stem Cell Research & Therapy. 09, 2016 | Pubmed ID: 27649756 Generation of Induced Cardiospheres Via Reprogramming of Skin Fibroblasts for Myocardial Regeneration Stem Cells (Dayton, Ohio). 11, 2016 | Pubmed ID: 27333945 Efficient Attenuation of Friedreich's Ataxia (FRDA) Cardiomyopathy by Modulation of Iron Homeostasis-human Induced Pluripotent Stem Cell (hiPSC) As a Drug Screening Platform for FRDA International Journal of Cardiology. Jan, 2016 | Pubmed ID: 26625322 Remodelling of Cardiac Sympathetic Re-innervation with Thoracic Spinal Cord Stimulation Improves Left Ventricular Function in a Porcine Model of Heart Failure Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. Mar, 2015 | Pubmed ID: 25767085 Pseudo-pre-excitation Unraveled Down to Its Core Circulation. Aug, 2014 | Pubmed ID: 25114190 Modeling of Friedreich Ataxia-related Iron Overloading Cardiomyopathy Using Patient-specific-induced Pluripotent Stem Cells Pflugers Archiv : European Journal of Physiology. Dec, 2013 | Pubmed ID: 24327207 Attenuation of Hind-limb Ischemia in Mice with Endothelial-like Cells Derived from Different Sources of Human Stem Cells PloS One. 2013 | Pubmed ID: 23472116 Patient-specific Induced-pluripotent Stem Cells-derived Cardiomyocytes Recapitulate the Pathogenic Phenotypes of Dilated Cardiomyopathy Due to a Novel DES Mutation Identified by Whole Exome Sequencing Human Molecular Genetics. Apr, 2013 | Pubmed ID: 23300193 Modeling of Lamin A/C Mutation Premature Cardiac Aging Using Patient‐specific Induced Pluripotent Stem Cells Aging. Nov, 2012 | Pubmed ID: 23362510 Reversal of Endothelial Progenitor Cell Dysfunction in Patients with Type 2 Diabetes Using a Conditioned Medium of Human Embryonic Stem Cell-derived Endothelial Cells Diabetes/metabolism Research and Reviews. Jul, 2012 | Pubmed ID: 22492468 Lack of Cardiac Nerve Sprouting After Intramyocardial Transplantation of Bone Marrow-derived Stem Cells in a Swine Model of Chronic Ischemic Myocardium Journal of Cardiovascular Translational Research. Jun, 2012 | Pubmed ID: 22302631 Cobalt Chloride Pretreatment Promotes Cardiac Differentiation of Human Embryonic Stem Cells Under Atmospheric Oxygen Level Cellular Reprogramming. Dec, 2011 | Pubmed ID: 22029419 Calcium Homeostasis in Human Induced Pluripotent Stem Cell-derived Cardiomyocytes Stem Cell Reviews. Nov, 2011 | Pubmed ID: 21614516 Exogenous Expression of Human ApoA-I Enhances Cardiac Differentiation of Pluripotent Stem Cells PloS One. May, 2011 | Pubmed ID: 21589943 Generation of Induced Pluripotent Stem Cell Lines from 3 Distinct Laminopathies Bearing Heterogeneous Mutations in Lamin A/C Aging. Apr, 2011 | Pubmed ID: 21483033 Ouabain Facilitates Cardiac Differentiation of Mouse Embryonic Stem Cells Through ERK1/2 Pathway Acta Pharmacologica Sinica. Jan, 2011 | Pubmed ID: 21151160 ROCK Inhibition Facilitates the Generation of Human-induced Pluripotent Stem Cells in a Defined, Feeder-, and Serum-free System Cellular Reprogramming. Dec, 2010 | Pubmed ID: 20858051 Proarrhythmic Risk of Embryonic Stem Cell-derived Cardiomyocyte Transplantation in Infarcted Myocardium Heart Rhythm : the Official Journal of the Heart Rhythm Society. Dec, 2010 | Pubmed ID: 20833268 Triiodothyronine Promotes Cardiac Differentiation and Maturation of Embryonic Stem Cells Via the Classical Genomic Pathway Molecular Endocrinology (Baltimore, Md.). Sep, 2010 | Pubmed ID: 20667986 Exogenous Expression of HIF-1 Alpha Promotes Cardiac Differentiation of Embryonic Stem Cells Journal of Molecular and Cellular Cardiology. Jun, 2010 | Pubmed ID: 20116384 Role of Circulating Endothelial Progenitor Cells in Patients with Rheumatoid Arthritis with Coronary Calcification The Journal of Rheumatology. Mar, 2010 | Pubmed ID: 20080904 Relationship of Circulating Endothelial Progenitor Cells to the Recurrence of Atrial Fibrillation After Successful Conversion and Maintenance of Sinus Rhythm Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. Apr, 2010 | Pubmed ID: 19951966 Effects of Iron Oxide Nanoparticles on Cardiac Differentiation of Embryonic Stem Cells Biochemical and Biophysical Research Communications. Feb, 2009 | Pubmed ID: 19135029 Paracrine Effects of Direct Intramyocardial Implantation of Bone Marrow Derived Cells to Enhance Neovascularization in Chronic Ischaemic Myocardium European Journal of Heart Failure. Aug, 2007 | Pubmed ID: 17481945 Normalization of Renal Aquaporin-2 Water Channel Expression by Fosinopril, Valsartan, and Combination Therapy in Congestive Heart Failure: a New Mechanism of Action Journal of Molecular and Cellular Cardiology. Mar, 2004 | Pubmed ID: 15010283 Establishing a Swine Model of Post-myocardial Infarction Heart Failure for Stem Cell Treatment Sijia Sun*1, Yu Jiang*1, Zhe Zhen1,2, Wing-Hon Lai1,2, Songyan Liao1,2, Hung-Fat Tse1,2 1Cardiology Division, Department of Medicine, Queen Mary Hospital, University of Hong Kong, 2Shenzhen Institutes of Research and Innovation, University of Hong Kong JoVE 60392 Medicina A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes Jiayin Yang*1,2,6, Lai-Yung Wong*2, Xiao-Yu Tian*3, Rui Wei1,2, Wing-Hon Lai2, Ka-Wing Au2, Zhiwei Luo4,5, Carl Ward4,5, Wai-In Ho2, David P. Ibañez4,5, Hao Liu4,5, Xichen Bao4,5, Baoming Qin4,5, Yu Huang3, Miguel A. Esteban4,5,7, Hung-Fat Tse1,2,6,7 1Department of Medicine, University of Hong Kong-Shenzhen Hospital, 2The Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, 3School of Biomedical Sciences, Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, 4Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University, 5Laboratory of RNA, Chromatin, and Human Disease, CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 6Research Centre of Heart, Brain, Hormone, and Healthy Ageing, Li Ka Shing Faculty of Medicine, University of Hong Kong, 7Hong Kong-Guangdong Stem Cell and Regenerative Medicine Research Centre, University of Hong Kong and Guangzhou Institutes of Biomedicine and Health JoVE 57556 Biologia do Desenvolvimento
Establishing a Swine Model of Post-myocardial Infarction Heart Failure for Stem Cell Treatment Sijia Sun*1, Yu Jiang*1, Zhe Zhen1,2, Wing-Hon Lai1,2, Songyan Liao1,2, Hung-Fat Tse1,2 1Cardiology Division, Department of Medicine, Queen Mary Hospital, University of Hong Kong, 2Shenzhen Institutes of Research and Innovation, University of Hong Kong JoVE 60392 Medicina
A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes Jiayin Yang*1,2,6, Lai-Yung Wong*2, Xiao-Yu Tian*3, Rui Wei1,2, Wing-Hon Lai2, Ka-Wing Au2, Zhiwei Luo4,5, Carl Ward4,5, Wai-In Ho2, David P. Ibañez4,5, Hao Liu4,5, Xichen Bao4,5, Baoming Qin4,5, Yu Huang3, Miguel A. Esteban4,5,7, Hung-Fat Tse1,2,6,7 1Department of Medicine, University of Hong Kong-Shenzhen Hospital, 2The Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, 3School of Biomedical Sciences, Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, 4Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University, 5Laboratory of RNA, Chromatin, and Human Disease, CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 6Research Centre of Heart, Brain, Hormone, and Healthy Ageing, Li Ka Shing Faculty of Medicine, University of Hong Kong, 7Hong Kong-Guangdong Stem Cell and Regenerative Medicine Research Centre, University of Hong Kong and Guangzhou Institutes of Biomedicine and Health JoVE 57556 Biologia do Desenvolvimento