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Journal / Neuroscience / Neural Tube Closure in Mouse Whole Embryo Culture
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Neuroscience

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JoVE Journal Neuroscience
Neural Tube Closure in Mouse Whole Embryo Culture
 

Neural Tube Closure in Mouse Whole Embryo Culture

Article DOI: 10.3791/3132-v • 07:37 min • October 21st, 2011
October 21st, 2011 •
1, 1
1Department of Neurology/Neuroscience, Weill Cornell Medical College

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Resumo
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A method allowing for direct pharmacological manipulation of mouse embryos during neurulation that bypasses maternal metabolism is described. The technique can be adapted to study different aspects of neurulation by varying the time point and pharmacological agent.

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Neural Tube Closure Mouse Embryos Embryo Culture Genetic Mouse Models Mammalian Neural Tube Closure Maternal Metabolism Pharmacological Manipulation Small Molecule Delivery Recombinant Protein Delivery SiRNA Delivery Whole Embryo Culture Enriched Media Roller Incubator Apparatus Normal Neural Tube Closure In Vitro Techniques Neurulation Neural Plate Formation Cranial Fold Closure Caudal Neuropore Closure Embryo Dissection
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