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Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging
 

Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging

Article DOI: 10.3791/50364-v • 10:50 min • June 29th, 2013
June 29th, 2013 •
*1,2, *1, 1, 1, 1, 1, 1
1The Texas Heart Institute at St. Luke's Episcopal Hospital, 2Department of Vascular Surgery, The Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University
* These authors contributed equally

Capítulos

Resumo
Automatic Translation

We show here the in vivo insertion of an osmotic pump for constant local drug delivery and the creation of hindlimb ischemia in a mouse model. Moreover, the hindlimb vasculature is perfused with Microfil, a silicone radiopaque agent, to prepare for micro-computed tomography (micro-CT) imaging.

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Keywords: Osmotic Drug Delivery Ischemic Hindlimb Microfil Perfusion Micro-computed Tomography Peripheral Arterial Disease Preclinical Research Animal Model Vascular Biology Angiogenesis Vascular Imaging
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