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Journal / Medicine / Production of Apolipoprotein C-III Knockout…
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Medicine

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JoVE Journal Medicine
Production of Apolipoprotein C-III Knockout Rabbits using Zinc Finger Nucleases
 

Production of Apolipoprotein C-III Knockout Rabbits using Zinc Finger Nucleases

Article DOI: 10.3791/50957-v • 10:59 min • November 18th, 2013
November 18th, 2013 •
1, 1, 1, 1, 1, 2, 1
1Center for Advanced Models for Translational Sciences and Therapeutics, Department of Internal Medicine, University of Michigan Medical Center, 2Department of Molecular Pathology, University of Yamanashi

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Recent development in gene targeting tools makes production of knockout (KO) rabbits possible. In the present work, we generated five Apolipoprotein (Apo) C-III KO rabbits using Zinc Finger Nucleases (ZFN). This work demonstrated that ZFN is a highly efficient method to produce KO rabbits.

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Keywords: Apolipoprotein C-III ApoCIII Knockout Rabbits Zinc Finger Nucleases Cardiovascular Diseases Lipid Metabolism Atherosclerosis
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