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Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits
 

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Article DOI: 10.3791/58964-v • 07:34 min • June 2nd, 2019
June 2nd, 2019 •
1, 2, 3, 2, 1, 2,4, 1,5,6,7
1Department of Biomedical Engineering, University of Texas at Austin, 2Division of Cardiology, University of Texas McGovern Medical School, 3Center for Laboratory Animal Medicine and Care, UT Health Science Center at Houston, 4Memorial Herman Heart and Vascular Center, Texas Medical Center, 5Institute for Cellular and Molecular Biology, University of Texas at Austin, 6The Institute for Computational Engineering and Sciences, University of Texas at Austin, 7Institute for Biomaterials, Drug Delivery and Regenerative Medicine, University of Texas at Austin

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We describe a surgical procedure used to induce peripheral ischemia in rabbits with hyperlipidemia and diabetes. This surgery acts as a preclinical model for conditions experienced in peripheral artery disease in patients. Angiography is also described as a means to measure the extent of introduced ischemia and recovery of perfusion.

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Keywords: Hind Limb Ischemia Diabetic Rabbits Peripheral Arterial Disease Regenerative Treatment Neovascularization Carotid Artery Heparin Guidewire Angiographic Catheter Contrast Agent Nitroglycerin Lidocaine
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