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A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies
 

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Article DOI: 10.3791/51253-v • 13:37 min • March 12th, 2014
March 12th, 2014 •
1, 1, 1, 1,2,4, 1,3,5, 1,3, 1,6
1Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, 2Department of Cellular and Molecular Medicine, University of Ottawa, 3Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 4Department of Neurosurgery, The Second Hospital of Shandong University, 5Department of Medical Laboratory Technology, University of Tabuk, 6Department of Surgery, Ottawa General Hospital

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A mouse tumor model of surgical stress is used to explore how postoperative immune suppression promotes metastatic disease and to evaluate immunostimulatory perioperative therapies.

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Keywords: Mouse Tumor Model Surgical Stress Postoperative Immunosuppression Perioperative Immunotherapies Cancer Surgery Metastatic Disease NK Cells 4T1 Breast Cancer Lung Metastases Immunotherapy
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