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JoVE Journal Neuroscience
Deep Brain Stimulation with Simultaneous fMRI in Rodents
 

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Article DOI: 10.3791/51271-v • 11:10 min • February 15th, 2014
February 15th, 2014 •
1,2,5, 1,2,4, 1,2,3,4
1Department of Neurology, University of North Carolina, 2Biomedical Research Imaging Center, University of North Carolina, 3Department of Biomedical Engineering, University of North Carolina, 4Curriculum in Neurobiology, University of North Carolina, 5School of Medicine, University of North Carolina

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This protocol describes a standard method for simultaneous functional magnetic resonance imaging and deep brain stimulation in the rodent. The combined use of these experimental tools allows for the exploration of global downstream activity in response to electrical stimulation at virtually any brain target.

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Deep Brain Stimulation FMRI Rodents BOLD Functional Magnetic Resonance Imaging Electrode Implantation MR Artifacts Anesthesia Paralytic Physiological Parameters Electrical Stimulation Tungsten Bipolar Microelectrode Sedation Paralysis Dexmedetomidine Pancuronium Isoflurane Subthalamic Nucleus (STN) Ipsilateral Cortical Regions
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