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JoVE Journal Neuroscience
Real-Time Impedance-based Cell Analyzer as a Tool to Delineate Molecular Pathways Involved in Neurotoxicity and Neuroprotection in a Neuronal Cell Line
 

Real-Time Impedance-based Cell Analyzer as a Tool to Delineate Molecular Pathways Involved in Neurotoxicity and Neuroprotection in a Neuronal Cell Line

Article DOI: 10.3791/51748-v • 08:23 min • August 9th, 2014
August 9th, 2014 •
1, 1, 1
1University Clinics for Child and Adolescent Psychiatry, University of Zürich

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Improved in vitro neurotoxicity assays would aid the identification of new neuroprotective compounds. The utility of a real-time impedance-based cell analyzer to determine cytotoxicity and cytoprotection in neuronal cell lines and to delineate the involvement of second messenger pathways, thus gaining insight in the mechanism of neuroprotection is presented.

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Keywords: Real-time Impedance-based Cell Analysis Neuronal Cell Line Neuroprotection Neurotoxicity 5-HT2A Receptor Agonists Second Messenger Pathways Cell Proliferation Cell Index Label-free Assessment
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