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Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution
 

Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution

Article DOI: 10.3791/51847-v • 09:59 min • July 4th, 2014
July 4th, 2014 •
1, 2, 1, 3, 1
1Optical Sciences Group, MESA+ Institute, University of Twente, 2Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine University, 3Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki

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Coherent anti-Stokes Raman scattering (CARS) microscopy is combined with an intrinsic flow-through dissolution setup to allow in situ and real-time visualization of the surface of pharmaceutical tablets undergoing dissolution. Using this custom-built setup, it is possible to correlate CARS videos with drug dissolution profiles recorded using inline UV absorption spectroscopy.

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Keywords: Coherent Anti-Stokes Raman Scattering (CARS) Microscopy Pharmaceutical Tablets Dissolution Theophylline Anhydrate Ethyl Cellulose Theophylline Monohydrate UV Absorption Spectroscopy Dissolution Rate Surface Composition Surface Structure
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