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JoVE Journal Neuroscience
Real-time Imaging of Axonal Transport of Quantum Dot-labeled BDNF in Primary Neurons
 

Real-time Imaging of Axonal Transport of Quantum Dot-labeled BDNF in Primary Neurons

Article DOI: 10.3791/51899-v • 10:53 min • September 15th, 2014
September 15th, 2014 •
1, 2, 1, 3,4, 1, 1
1Department of Neurosciences, University of California, San Diego, 2School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, 3Department of Anesthesiology, University of California, San Diego, 4VA San Diego Healthcare System

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Axonal transport of BDNF, a neurotrophic factor, is critical for the survival and function of several neuronal populations. Some degenerative disorders are marked by disruption of axonal structure and function. We demonstrated the techniques used to examine live trafficking of QD-BDNF in microfluidic chambers using primary neurons.

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Axonal Transport BDNF Quantum Dot Neurodegenerative Disease Microfluidic Device Retrograde Transport Axonal Function
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