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gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
 

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Article DOI: 10.3791/51902-v • 08:15 min • October 6th, 2014
October 6th, 2014 •
1, 1
1Department of Biology and Pathology of Tumors, Unit of Molecular Biology, Platform of Immunomonitoring and Genetics, Centre Georges-François Leclerc

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gDNA enrichment for NGS sequencing is an easy and powerful tool for the study of constitutional mutations. In this article, we present the procedure to analyse simply the complete sequence of 11 genes involved in DNA damage repair.

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Keywords: NGS Next-generation Sequencing Cancer Genetics DNA Damage Repair BRCA1 BRCA2 Transposase-based Technology GDNA Enrichment Genetic Diagnosis Sample Multiplexing
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