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3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse
 

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse

Article DOI: 10.3791/52328-v • 15:26 min • May 19th, 2015
May 19th, 2015 •
1, 1, 1, 1, 1, 1, 2, 1
1Department of Physiology and Neurobiology, University of Connecticut, 2Department of Anatomic Pathology and Laboratory Medicine, University of Connecticut Health Center

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Using MRI scans (human), 3D imaging software, and immunohistological analysis, we document changes to the brain’s lateral ventricles. Longitudinal 3D mapping of lateral ventricle volume changes and characterization of periventricular cellular changes that occur in the human brain due to aging or disease are then modeled in mice.

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3D Modeling Lateral Ventricles Histological Characterization Periventricular Tissue Ventricular System Cerebral Spinal Fluid (CSF) Solutes Toxins Ependymal Cells Ciliary Action Laminar Flow Brain Interstitial Fluids (ISF) Barrier Function Filtration Function CSF And ISF Exchange Ventriculomegaly Aging Dementia Obstruction Of CSF Flow Astrogliosis Periventricular Edema MRI Scans Postmortem Human Brain Tissue
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