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JoVE Journal Neuroscience
3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse
 

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse

Article DOI: 10.3791/52328-v • 15:26 min • May 19th, 2015
May 19th, 2015 •
1, 1, 1, 1, 1, 1, 2, 1
1Department of Physiology and Neurobiology, University of Connecticut, 2Department of Anatomic Pathology and Laboratory Medicine, University of Connecticut Health Center

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Using MRI scans (human), 3D imaging software, and immunohistological analysis, we document changes to the brain’s lateral ventricles. Longitudinal 3D mapping of lateral ventricle volume changes and characterization of periventricular cellular changes that occur in the human brain due to aging or disease are then modeled in mice.

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Keywords: 3D Modeling Lateral Ventricles Ependymal Cells Ventriculomegaly Cerebral Spinal Fluid Brain Aging Periventricular Tissue Immunohistochemistry MRI Mouse Models
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