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JoVE Journal Bioengineering
Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
 

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Article DOI: 10.3791/52735-v • 11:43 min • April 3rd, 2015
April 3rd, 2015 •
1, 2, 2,3
1Systems Biophysics Department, FOM Institute AMOLF, 2Mechanobiology Institute, National University of Singapore, 3Department of Biomedical Engineering, National University of Singapore

Capítulos

Resumo
Automatic Translation

The mechanical properties and microstructure of the extracellular matrix strongly affect 3D migration of cells. An in vitro method to study the spatiotemporal cell migration behavior in biophysically variable environments, at both population and individual cell levels, is described.

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Keywords: 3D Cell Migration Cell Invasion Extracellular Matrix Mechanosensing Breast Cancer Cells Collagen Gels Live-cell Imaging Biophysical Microenvironment
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