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Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis
 

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

Article DOI: 10.3791/52800-v • 07:05 min • May 17th, 2015
May 17th, 2015 •
1, 1, 1
1Department of Molecular Biology and Biochemistry, Simon Fraser University

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We describe a protocol for aortic interposition grafting in mice. The goal of the protocol is to provide a model with which to study pathological processes and therapeutic strategies relevant to alloimmune reactions in arteries and the resultant arterial changes that contribute to organ transplant failure.

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Keywords: Mouse Model Alloimmune-induced Vascular Rejection Transplant Arteriosclerosis Chronic Heart Transplant Failure Immune System Endothelial Cells Smooth Muscle Cells Intimal Thickening Luminal Occlusion Aortic Interposition Model Allogeneic Vascular Rejection Arterial Changes
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