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Immunology and Infection

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JoVE Journal Immunology and Infection
A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
 

A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis

Article DOI: 10.3791/55453-v • 10:29 min • March 24th, 2017
March 24th, 2017 •
1, 1, 1, 1, 1
1Department of Medicine, University of Alabama at Birmingham

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New models and assays that would improve the early drug development process for next-generation anti-tuberculosis drugs are highly desirable. Here, we describe a quick, inexpensive, and BSL-2 compatible assay to evaluate drug efficacy against Mycobacterium tuberculosis that can be easily adapted for high-throughput screening.

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Keywords: Macrophage Mycobacterium Tuberculosis Drug Efficacy High-throughput BSL2 THP1 Cells GFP Viability Dye Drug Susceptibility Anti-tuberculosis Compounds Granulomas In Vivo Efficacy
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