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Immunology and Infection

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JoVE Journal Immunology and Infection
System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
 

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Article DOI: 10.3791/55273-v • 09:57 min • April 5th, 2017
April 5th, 2017 •
1, 1
1Department of Medicine, University of British Columbia

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We have developed a modular high-throughput screening system for discovering novel compounds against Mycobacterium tuberculosis, targeting intracellular and in-broth growing bacteria as well as cytotoxicity against the mammalian host cell.

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Keywords: Mycobacterium Tuberculosis Intracellular Infection Macrophages Luciferase Assay Cytotoxicity MIC Drug Development THP1 Cells Opsonization MOI Differentiation 96-well Plate Compound Screening
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