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Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
 

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

Article DOI: 10.3791/55850-v • 09:24 min • August 22nd, 2017
August 22nd, 2017 •
1, 1, 2, 3, 4, 4, 4
1Department of Attribute Sciences, Amgen, Inc., 2Small Molecule Pharmaceutical Sciences, Genentech, Inc., 3NMR Service + Consulting, 4Mestrelab Research

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A simple and non-destructive technique that measures the average content of drug substances in formulated drug products containing fluorine using low-field fluorine-19 (19F) time-domain (TD) nuclear magnetic resonance (NMR) is presented here. The technique can be applied to the development and manufacturing of drugs in the pharmaceutical industry.

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Keywords: 19F NMR Non-destructive Analysis Drug Content Pharmaceuticals Formulation Calibration T1 Relaxation Time API RINMR Software
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