Waiting
Processando Login

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Chemistry / A New Straightforward Method for Lipophilicity…
JoVE Journal
Chemistry

É necessário ter uma assinatura JoVE para assistir este Faça login ou comece sua avaliação gratuita.

JoVE Journal Chemistry
A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy
 

A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy

Article DOI: 10.3791/58567-v • 09:32 min • January 30th, 2019
January 30th, 2019 •
1, 1, 1, 1, 2, 1
1Chemistry, University of Southampton, 2Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca

Capítulos

Resumo
Automatic Translation

A novel and straightforward variation of the shake-flask method was developed for accurate lipophilicity measurement of fluorinated compounds by 19F NMR spectroscopy.

Tags

Lipophilicity LogP Measurement 19F NMR Spectroscopy Lipophilicity Measurement Fluorine NMR Organic Compounds Medicinal Chemistry Reference Compound Sampling NMR Tube Sealing NMR Software Compound X HPLC-grade N-Octanol HPLC-grade Water Temperature Controlled Receptacle Stir Plate Recirculating Chiller
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter