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JoVE Journal Neuroscience
Modeling Amyloid-β42 Toxicity and Neurodegeneration in Adult Zebrafish Brain
 

Modeling Amyloid-β42 Toxicity and Neurodegeneration in Adult Zebrafish Brain

Article DOI: 10.3791/56014-v • 10:01 min • October 25th, 2017
October 25th, 2017 •
1, 2, 1, 1, 3, 2, 1,3
1German Centre for Neurodegenerative Diseases (DZNE) Dresden within Helmholtz Association, 2B CUBE, Center for Molecular Bioengineering, Technische Universität Dresden, 3Center for Regenerative Therapies Dresden (CRTD), TU Dresden

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This protocol describes the synthesis, characterization, and injection of monomeric amyloid-β42 peptides for generating amyloid toxicity in adult zebrafish to establish an Alzheimer's disease model, followed by histological analyses and detection of aggregations.

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Amyloid-beta 42 Toxicity Neurodegeneration Zebrafish Brain Alzheimer's Disease Model Amyloid Toxicity Neural Stem Cells Rejuvenation Response Alzheimer's Disease Therapy Vertebrate Model Amyloid Beta 42 Peptide Synthesis Peptide Synthesizer
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