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Immunology and Infection

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JoVE Journal Immunology and Infection
Alternative In Vitro Methods for the Determination of Viral Capsid Structural Integrity
 

Alternative In Vitro Methods for the Determination of Viral Capsid Structural Integrity

Article DOI: 10.3791/56444-v • 12:57 min • November 16th, 2017
November 16th, 2017 •
1, 2, 1
1Department of Food, Bioprocessing, and Nutrition Sciences, North Carolina State University, 2Department of Chemical and Biomolecular Engineering, North Carolina State University

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Routine detection methods utilizing viral genome amplification are limited by their inability to discriminate infectious from non-infectious particles. The purpose of this article is to provide detailed protocols for alternative methods to aid in discrimination of infectious norovirus particles using aptamer binding, dynamic light scattering, and transmission electron microscopy.

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Keywords: Viral Capsid Structural Integrity In Vitro Methods Norovirus Viral Inactivation Capsid Protein Heat Treatment Aptamer ELISA
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