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In Vivo Evaluation of Fracture Callus Development During Bone Healing in Mice Using an MRI-compatible Osteosynthesis Device for the Mouse Femur
 

In Vivo Evaluation of Fracture Callus Development During Bone Healing in Mice Using an MRI-compatible Osteosynthesis Device for the Mouse Femur

Article DOI: 10.3791/56679-v • 07:33 min • November 14th, 2017
November 14th, 2017 •
1, 1,4, 2, 3, 1, 4, *3, *1
1Institute of Orthopedic Research and Biomechanics, University Medical Center Ulm, 2RISystem, 3Core Facility Small Animal MRI, University Medical Center Ulm, 4Department of Traumatology, Hand-, Plastic-, and Reconstructive Surgery, University Medical Center Ulm
* These authors contributed equally

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Resumo
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The evaluation of tissue development in the fracture callus during endochondral bone healing is essential to monitor the healing process. Here, we report the use of a magnetic resonance imaging (MRI)-compatible external fixator for the mouse femur to allow MRI scans during bone regeneration in mice.

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MRI-compatible Osteosynthesis Device Fracture Callus Development Bone Healing Mice Longitudinal Evaluation Magnetic Resonant Imaging Mouse Models External Fixator In Vivo Monitoring Real-time Standardized Fracture Healing Model Small Animal Imaging Core Facility Sedation Antibiotics Surgical Procedure
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