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Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting
 

Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting

Article DOI: 10.3791/58480-v • 08:15 min • October 26th, 2018
October 26th, 2018 •
1, 1, 1
1Center of Biomedical Education and Research, University Witten/Herdecke

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The protocol described here enables researchers to specifically modify adenovirus capsids at selected sites by simple chemistry. Shielded adenovirus vectors particles and retargeted gene transfer vectors can be generated, and vector host interactions can be studied.

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Keywords: Gene Therapy Oncolysis Genetic Vaccination Adenovirus Gene Transfer Vector Capsid Modification Chemical Modification Vector-host Interaction Virus Labeling Virus Tracking
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