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Immunology and Infection

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JoVE Journal Immunology and Infection
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
 

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Article DOI: 10.3791/59667-v • 07:15 min • January 21st, 2020
January 21st, 2020 •
1,2, 1,2
1Department of Dental Oncology and Maxillofacial Prosthetics, Princess Margaret Cancer Centre, University Health Network, 2Faculty of Dentistry, University of Toronto

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This article presents a protocol for establishing a ligature-induced model of murine periodontitis involving multiple maxillary molars, resulting in larger areas of the involved gingival tissue and bone for subsequent analysis as well as reduced animal usage. A technique to assess oral neutrophils in a manner analogous to human subjects is also described.

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Keywords: Ligature-induced Murine Periodontitis Oral Neutrophils Gingival Tissues Microsurgical Instruments Surgical Microscope Braided Silk Suture Maxillary Molars Gingival Sulcus Surgeon's Knot
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