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Immunology and Infection
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JoVE Journal Immunology and Infection
Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
 

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Article DOI: 10.3791/64842-v • 06:14 min • February 17th, 2023
February 17th, 2023 •
1,2, 1, 1,2,3, 1,2,4,5, 1,2,4,5
1Group of Cell Therapy and Tissue Engineering, Research Institute on Health Sciences (IUNICS), University of the Balearic Islands (UIB), 2Balearic Islands Health Research Institute (IdISBa), 3Preclinical Research Department, Labo'Life España, 4Departament de Biologia Fonamental i Ciències de la Salut, UIB, 5ADEMA School of Dentistry, UIB

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In this study, a rat model of induction of periodontitis is presented via a combination of retentive ligature and repetitive injections of lipopolysaccharide derived from Porphyromonas gingivalis, over 14 days around the first maxillary molars. The ligation and LPS injection techniques were effective in inducing peridontitis, resulting in alveolar bone loss and inflammation.

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Keywords: Periodontitis Rat Model Ligature Lipopolysaccharide Experimental Inflammatory Response Alveolar Bone Resorption Connective Tissue Loss Periodontal Disease Treatment Evaluation
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