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JoVE Journal Neuroscience
Hybrid Microdrive System with Recoverable Opto-Silicon Probe and Tetrode for Dual-Site High Density Recording in Freely Moving Mice
 

Hybrid Microdrive System with Recoverable Opto-Silicon Probe and Tetrode for Dual-Site High Density Recording in Freely Moving Mice

Article DOI: 10.3791/60028-v • 08:57 min • August 10th, 2019
August 10th, 2019 •
1, 1,2, 1
1Department of Psychiatry, University of Texas Southwestern Medical Center, 2Department of Neuroscience, University of Texas Southwestern Medical Center

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This protocol describes the construction of a hybrid microdrive array that allows implantation of nine independently adjustable tetrodes and one adjustable opto-silicon probe in two brain regions in freely moving mice. Also demonstrated is a method for safely recovering and reusing the opto-silicon probe for multiple purposes.

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