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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
 

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Article DOI: 10.3791/60184-v • 08:59 min • December 3rd, 2020
December 3rd, 2020 •
1, 4, 1, 1,2, 1, 1, 1, 3, 3, 1
1Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), 2Brazilian Synchrotron Light Laboratory (LNLS), Brazilian Center for Research in Energy and Materials (CNPEM), 3Grupo Boticário, 4Institute of Biology, University of Campinas

Resumo
Automatic Translation

We exposed a microphysiological system (MPS) with intestine and liver organoids to acetaminophen (APAP). This article describes the methods for organoid production and APAP pharmacokinetic and toxicological property assessments in the MPS. It also describes the tissue functionality analyses necessary to validate the results.

Tags

Keywords: Microphysiological System Pharmacokinetic Assessment Toxicological Assessment Intestine Liver Drug Testing In Vitro Organ-on-a-chip Acetaminophen HPLC Analysis Cell Viability
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