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JoVE Journal Genetics
Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
 

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Article DOI: 10.3791/60215-v • 09:40 min • October 4th, 2019
October 4th, 2019 •
1, 1
1Department of Neurosurgery, Brigham and Women's Hospital-Harvard Medical School

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Described here is a protocol for characterizing modules of biologically synergistic miRNAs and their assembly into short transgenes, which allows simultaneous overexpression for gene therapy applications.

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Keywords: MiRNA MicroRNA Glioblastoma Gene Therapy Artificial MiRNA Clusters Neural Stem Cells GBM-34 Glioblastoma Stem-like Cells Temozolomide Bioinformatics Gene Expression Cancer Poly-D-lysine Cell Culture In Vitro
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