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JoVE Journal Neuroscience
Generation af humane hjerneorganoider til mitokondriesygdom Modellering
 
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Generation af humane hjerneorganoider til mitokondriesygdom Modellering

Article DOI: 10.3791/62756-v • 08:09 min • June 21st, 2021
June 21st, 2021 •
1, 2, 1,4, 1, 2, 3, 3, 2, 1,5
1Department of General Pediatrics, Neonatology and Pediatric Cardiology, Duesseldorf University Hospital, Medical Faculty, Heinrich Heine University, 2Institute of Neurobiology, Heinrich Heine University, 3Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrueck Center for Molecular Medicine (MDC), 4Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, 5Max Delbrueck Center for Molecular Medicine (MDC)

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Vi beskriver en detaljeret protokol for generering af menneskeskabte pluripotente stamcelle-afledte hjerneorganoider og deres anvendelse i modellering mitokondrie sygdomme.

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Neurovidenskab hjerneorganoider iPSCs mitokondriesygdom bioenergetisk profilering
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