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JoVE Journal Neuroscience
Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity
 

Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity

Article DOI: 10.3791/63081-v • 08:16 min • September 21st, 2021
September 21st, 2021 •
*1, *2, 1,3, 1, 3, 3, 1
1Institute for Food Nutrition and Human Health, School of Food Science and Engineering, South China University of Technology, 2School of Bioscience and Bioengineering, Hebei University of Economics and Business, 3Perfect Life & Health Institute
* These authors contributed equally

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Here, we present a protocol to assess the neuroprotective activities of test compounds in Caenorhabditis elegans, including polyglutamine aggregation, neuronal death, and chemoavoidance behavior, as well as an exemplary integration of multiple phenotypes.

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Caenorhabditis Elegans Model System Bioactive Compounds Polyglutamine-mediated Neurotoxicity Screening Evaluating Huntington's Disease-like Models Phenotypes C.elegans Models Neurodegenerative Diseases Therapeutic Candidates Temperatures Growth Stages Synchronized L1 Larvae 48 Well Plate S Medium OP50 Strain Of E.coli Astragalan Parafilm Incubate M9 Buffer
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