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JoVE Journal Bioengineering
In Silico Clinical Trials for Cardiovascular Disease
 

In Silico Clinical Trials for Cardiovascular Disease

Article DOI: 10.3791/63573-v • 09:09 min • May 27th, 2022
May 27th, 2022 •
1,2, 2,3, 1,2, 2,3, 1,2, 2,3, 1,4, 1,5
1Bioengineering Research and Development Center BioIRC, 2Faculty of Engineering, University of Kragujevac, 3Institute for Information Technology, University of Kragujevac, 4Faculty of Science, University of Kragujevac, 5Serbian Academy of Science and Arts

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This protocol demonstrates the workflow of the SILICOFCM platform for automatically generating a parametric model of the left ventricle from patient-specific ultrasound images by applying a multi-scale electromechanical model of the heart. This platform enables in silico clinical trials intended to reduce real clinical trials and maximize positive therapeutic outcomes.

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Keywords: In Silico Clinical Trials Cardiovascular Disease Silico FCM Platform Left Ventricle Patient-specific Ultrasound Images Electromechanical Model Heart Drug Effects Boundary Conditions ECG Calcium Function Heart Muscle Cardiomyopathy Heart Failure Cardiac Ischemia Arrhythmia Atrial Fibrillation Virtual Population Module Ultrasound M-Mode Apical View Workflow DICOM Files Geometry Shaded Model Wire Frame Model Inlet And Outlet Velocities Finite Element Mesh Patient-specific Condition
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