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Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
 

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Article DOI: 10.3791/63866-v • 06:19 min • September 9th, 2022
September 9th, 2022 •
*1, *1, 1,2, 1, 1, 1, 1, 1, 1, 1, 3, 1
1Putuo People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, 2National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 3Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University
* These authors contributed equally

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The present protocol describes the induction of experimental autoimmune encephalomyelitis in a mouse model using myelin oligodendrocyte glycoprotein and monitoring the disease process using a clinical scoring system. Experimental autoimmune encephalomyelitis-related symptoms are analyzed using mouse femur micro-computed tomography analysis and open field test to assess the disease process comprehensively.

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Keywords: Experimental Autoimmune Encephalomyelitis Multiple Sclerosis Myelin Oligodendrocyte Glycoprotein Peptide Freud's Adjuvant Pertussis Toxin Open Field Reaction Chamber Mouse Locomotion
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