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用于生产PET示踪剂的固体阶段11C甲基化、纯化和配方
JoVE Journal
Chemistry
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JoVE Journal Chemistry
Solid Phase 11C-Methylation, Purification and Formulation for the Production of PET Tracers
DOI:

09:25 min

October 24, 2019

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Chapters

  • 00:05Title
  • 01:04Preparation of Buffers and Eluents
  • 02:10Application of the Precursor to the Cartridge
  • 03:19Setting up the Manifold for Automated Synthesis
  • 04:13Radiosynthesis of [11C]PiB
  • 06:46Quality Control Procedures
  • 07:35Results: Radiosynthesis of [11C]PiB
  • 08:53Conclusion

Summary

Automatic Translation

我们报告一种高效的碳-11放射性标签技术,使用固体相提取盒生产与正电子发射断层扫描(PET)相关的临床示踪剂。11C甲基化剂通过预装前体的盒,并连续用水乙醇洗脱提供高放射性化学产量的化学和放射化学纯PET示踪剂。

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