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合成的<em>在体内</em> MRI检测细胞凋亡的探讨
JoVE Journal
Biology
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JoVE Journal Biology
Synthesis of an In vivo MRI-detectable Apoptosis Probe
DOI:

06:58 min

July 31, 2012

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Chapters

  • 00:05Title
  • 01:05Conjugation of Annexin V to SPIO and Dynamic Light Scattering
  • 03:19Cell Culture, Induction of Apoptosis in Culture, and MRI of Cultured Cells
  • 04:16In vitro MRI
  • 05:32Representative MRI Results
  • 06:38Conclusion

Summary

Automatic Translation

细胞凋亡的早期检测可以识别处于危险的细胞群,在多种疾病。在这里,我们展示了一个方法来链接早期凋亡检测蛋白Annexin V的一个MRI检测的氧化铁纳米粒子(超顺磁性氧化铁)。此方法可扩展到其他感兴趣的蛋白质生成MRI检测的分子成像探针。

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