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Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
 

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Article DOI: 10.3791/56075-v • 09:51 min • July 26th, 2017
July 26th, 2017 •
1, 2, 1, 1, 2
1Department of Respiratory Medicine, Shanghai First People's Hospital, Shanghai Jiaotong University School of Medicine, 2Department of Pediatrics, BC Children's Hospital and University of British Columbia

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Summary
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Toll-like receptor (TLR) signaling plays an important role in the pathophysiology of many human inflammatory diseases, and regulating TLR responses by bioactive nanoparticles is anticipated to be beneficial in many inflammatory conditions. THP-1 cell-based reporter cells provide a versatile and robust screening platform for identifying novel inhibitors of TLR signaling.

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Keywords: Bioactive Nanoparticles Toll-like Receptor Signaling Innate Immune Cells Inflammatory Diseases Phagocytic Immune Cells Reporter Cell Systems Nanoinhibitors Screening Procedure Luciferase Substrate SEAP Substrate Cell Culture PMA
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