A subscription to JoVE is required to view this content. Sign in or start your free trial.
1Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry,University Hospital Tübingen, 2Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich,University Tübingen, 3German Center for Diabetes Research (DZD),University Tübingen
Chapters
- 00:04Title
- 00:54Inducing Experimental Nephrotic Syndrome with Doxorubicin
- 02:24Implantation of Sustained-Release Pellets Containing Aprotinin
- 04:01Assessing Urine Serine Protease Activity
- 05:32Results: Analysis of Doxorubicin-induced Nephrotic Syndrome
- 06:48Conclusion
Her beskriver vi induktion af eksperimentelle Nefrotisk syndrom i 129S1/SvImJ mus ved hurtig retrobulbær injektion af doxorubicin. Vi behandler også nefrotisk mus med vedvarende frigivelse piller indeholdende aprotinin for at hæmme urin Serin protease aktivitet og forhindre natrium fastholdelse.
