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Protocolo do Banco Cerebral Abbiategrasso para coleta, processamento e caracterização de cérebros envelhecidos
This content is Free Access.
1Department of Neurology and Neuropathology,Golgi-Cenci Foundation, 2Laboratory of Neurobiology and Neurogenetic,Golgi-Cenci Foundation, 3Department of Neuropsychology and Social Sciences,Golgi-Cenci Foundation, 4Department of Rehabilitation,ASP Golgi-Redaelli Geriatric Hospital, 5Genomic and Post-Genomic Center,IRCCS Mondino Foundation, 6Department of Brain and Behavioral Sciences,University of Pavia, 7Department of Pathology,ASP Golgi-Redaelli Geriatric Hospital, 8Department of Neurological Science, IRCCS Mondino Foundation,University of Pavia
Chapters
- 00:04Introduction
- 01:28Time of Death and Brain Removal
- 05:23Abbiategrasso Brain Bank (ABB) Dissection
- 08:26Tissue Freezing and Fixation
- 09:17Results: Representative Brain Specimen Characterization and Analyses
- 11:13Conclusion
Este protocolo descreve um método para rastrear trajetórias individuais de envelhecimento cerebral através de um programa de doação cerebral e caracterização adequada de cérebros. Doadores cerebrais estão envolvidos em um estudo longitudinal de longo prazo, incluindo avaliações multidimensionais em série. O protocolo contém uma descrição detalhada do processamento cerebral e uma metodologia de diagnóstico precisa.
Tags
Brain BankAging BrainNeurocognitive DisorderNeuropathological FindingsDefinite DiagnosisBrain DamageMultiple PathologiesFresh Cutting ProceduresMacro Section ManagementThanatographyScalp IncisionSkull CapMeningesCerebral Spinal FluidBrain HarvestNeurodegenerative MechanismsDeep LearningPathogenesisTherapiesDuraCorpus CallosumThird Ventricle
