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数据集成工作流,以识别针对合成致命相互作用的药物组合
JoVE Journal
Cancer Research
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JoVE Journal Cancer Research
A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
DOI:

07:40 min

May 27, 2021

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Chapters

  • 00:04Introduction
  • 01:03Retrieving Synthetic Lethal Gene Pairs
  • 01:48Translating Synthetic Lethal Gene Pairs to Human Orthologs
  • 03:20Mapping Synthetic Lethal Interaction Partners to Drugs
  • 04:28Establish the Set of Currently Tested Drug Combinations in Clinical Trials
  • 04:45Testing Proposed Drug Combinations In Vitro
  • 05:28Results: Proposed Novel Drug Combinations for Ovarian and Breast Cancer
  • 06:37Conclusion

Summary

Automatic Translation

模型生物体中的大型基因筛选导致对负基因相互作用的识别。在这里,我们使用模型生物体中遗传筛选的数据来描述数据集成工作流,以描述针对癌症中合成致命相互作用的药物组合。

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