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JoVE Journal Cancer Research
In Vivo Targeting of Xenografted Human Cancer Cells with Functionalized Fluorescent Silica Nanoparticles in Zebrafish
 

In Vivo Targeting of Xenografted Human Cancer Cells with Functionalized Fluorescent Silica Nanoparticles in Zebrafish

Article DOI: 10.3791/61187-v • 10:26 min • May 8th, 2020
May 8th, 2020 •
*1, *1, 2, 1, 2,3,4, 1
1Departments of Pharmacology and Medicine, Section of Hematology and Medical Oncology, The Cancer Research Center, Boston University School of Medicine, 2Department of Biomedical Engineering, Tufts University, 3Department of Mechanical Engineering, Tufts University, 4Department of Physics, Tufts University
* These authors contributed equally

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Summary
Automatic Translation

Described here is a method for utilizing zebrafish embryos to study the ability of functionalized nanoparticles to target human cancer cells in vivo. This method allows for the evaluation and selection of optimal nanoparticles for future testing in large animals and in clinical trials.

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Keywords: In Vivo Xenografted Human Cancer Cells Fluorescent Silica Nanoparticles Zebrafish Targeting Nanomaterials Cancer Research Animal Models Drug Delivery Bioimaging
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